文章摘要

胃癌组织YAP1、E-cadherin、N-cadherin表达及临床意义

作者: 1肖 磊, 1黄 昌浩, 1袁 伟杰, 1陈 晋湘, 2骆 晴晴, 1陈 子华
1 中南大学湘雅医院胃肠外科,湖南 长沙 410008
2 中南大学湘雅医院 肿瘤科,湖南 长沙 410008
通讯: 陈 子华 Email: zihuac@126.com
DOI: 10.3978/.2018.04.009
基金: 湖南省自然科学基金资助项目(2015JJ4049)。

摘要

目的:探讨YAP1、E-cadherin、N-cadherin在胃癌组织中表达及意义。
方法:用免疫组化法检测胃癌组织芯片中135例患者癌组织和癌旁组织中YAP1、E-cadherin、N-cadherin表达,分析YAP1表达与E-cadherin、N-cadherin表达的关系,以及与胃癌患者临床病理因素以及预后的关系。
结果:与癌旁组织比较,胃癌组织中YAP1表达明显升高,E-cadherin表达明显降低(均P<0.05),N-cadherin表达无明显差异(P>0.05);在胃癌组织中,YAP1表达与E-cadherin表达呈负相关(r=-0.273,P=0.032),与N-cadherin表达呈正相关(r=0.304,P=0.019)。YAP1在胃癌组织中的表达与胃癌患者淋巴转移、脉管侵犯有关(均P<0.05),且YAP1阳性表达患者总生存率明显低于阴性表达患者(χ2=4.354,P=0.037)。
结论:YPA1与E-cadherin在胃癌组织中表达有明显变化,YAP1高表达与胃癌患者不良临床病理特征及预后密切相关。
关键词: 胃肿瘤;YES相关蛋白;上皮-间质转化;预后

Expressions of YAP1, E-cadherin and N-cadherin in gastric cancer tissue and their clinical significance

Authors: 1XIAO Lei, 1HUANG Changhao, 1YUAN Weijie, 1CHEN Jinxiang, 2LUO Qingqing, 1CHEN Zihua
1 Department of Gastrointestinal Surgery, Central South University, Changsha 410008, China
2 Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China

CorrespondingAuthor:CHEN Zihua Email: zihuac@126.com

Abstract

Objective: To investigate the expressions of YAP1, E-cadherin and N-cadherin in gastric cancer tissue and their significance.
Methods: The expressions of YAP1, N-cadherin and E-cadherin proteins in tissue microarray containing 135 samples of gastric cancer tissue and adjacent tissue were determined by immunohistochemical staining. The relations of YAP1 expression with E-cadherin and N-cadherin expressions as well as with clinicopathologic characteristics and prognosis of the patients were analyzed.
Results: In gastric cancer tissue compared with adjacent non-tumor tissue, the YAP1 expression was increased and E-cadherin expression was decreased significantly (both P<0.05), but the N-cadherin showed no significant difference (P>0.05). There was a negative correlation between YAP1 expression and E-cadherin expression (r=–0.273, P=0.032), and a positively correlation between YAP1 expression and N-cadherin (r=0.304, P=0.019) in gastric cancer tissue. The expression of YAP1 in gastric cancer was correlated with lymphatic metastasis and vascular invasion (P<0.05), and the overall survival rate in patients with YAP1 positive expression was significantly lower than that in those with YAP1 negative expression (χ2=4.354, P=0.037).
Conclusion: The expressions of YPA1 and E-cadherin are significantly changed in gastric cancer tissue, and high YAP1 expression is closely related to the unfavorable clinicopathologic features and poor prognosis in the gastric cancer patients.
Keywords: Stomach Neoplasms; Yes-Associated Proteins; Epithelial-Mesenchymal Transition; Prognosis