文章摘要

伊马替尼对胃肠间质瘤患者Foxp3+ Treg影响的研究进展

作者: 1陈 小龙, 1冯 立波, 1巫 晓龙, 1左 忠林, 1陈 鹏, 1刘 亿, 1邹 庆伟, 1刘 庆, 1夏 冬
1 西南医科大学附属医院 胃肠外科,四川 泸州 646000
通讯: 夏 冬 Email: juliahhy@aliyun.com
DOI: 10.3978/.2018.04.015
基金: 四川省教育厅资助项目(16ZA0197)。

摘要

胃肠间质瘤(GIST)是胃肠道最常见的间叶源性肿瘤,多数GIST发病机制是c-Kit基因发生功能获得性突变,表达Kit蛋白并持续激活其下游信号通路使肿瘤细胞持续增殖。作为酪氨酸激酶抑制剂,伊马替尼在GIST中的应用使得靶向治疗成为手术治疗以外最为重要的治疗方式,已深刻影响了GIST的治疗模式。Foxp3+ Treg是体内重要的调节性T细胞,通过抑制CTL、NK细胞等肿瘤抑制细胞的功能,负向调节机体的抗肿瘤免疫反应。研究显示,伊马替尼不仅可通过靶向治疗机制,也可能通过抑制Foxp3+ Treg细胞而增强机体对肿瘤的免疫反应,从免疫途径发挥治疗GIST的作用。笔者就伊马替尼对GIST患者外周血中Foxp3+ Treg细胞及其亚群影响的相关研究作一综述。
关键词: 胃肠道间质肿瘤;甲磺酸伊马替尼;T淋巴细胞,调节性;综述文献

RResearch progress of effects of imatinib on Foxp3+Treg cells in patients with gastrointestinal stromal tumor

Authors: 1CHEN Xiaolong, 1FENG Libo, 1WU Xiaolong, 1ZUO Zhonglin, 1CHEN Peng, 1LIU Yi, 1ZOU Qingwei, 1LIU Qing, 1XIA Dong
1 Department of the Gastrointestinal Surgery, the Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China

CorrespondingAuthor:XIA Dong Email: juliahhy@aliyun.com

Abstract

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. The mechanism for most GIST is considered to be the gain-of-function mutations of the c-Kit gene and Kit protein expression which cause the sustained activation of its down-stream signaling pathways and thereby the continuous proliferation of the tumor cells. As a tyrosine kinase inhibitor, application of imatinib has allowed the targeted therapy to become an important therapeutic option besides surgical treatment for GIST, and significantly influenced the treatment mode of GIST. Foxp3+Treg cells are important regulatory T population, and they negatively control the anti-tumor immune responses through suppressing the anti-tumor cells such as CTL and NK cells. Studies have revealed that imatinib inhibits GIST through not only targeted mechanism but also immunological mechanisms by suppressing the Foxp3+Treg cells and enhancing the anti-tumor immune responses. Here, the authors present research progress of the effects of imatinib on the peripheral blood Foxp3+Treg cells and their subpopulations in patients with GIST.
Keywords: Gastrointestinal Stromal Tumors; Imatinib Mesylate; T-Lymphocytes Regulatory; Review