文章摘要

分化型甲状腺癌的术前分子诊断的发展现状及前景思考

作者: 1于 洋, 1关 海霞
1 中国医科大学附属第一医院 内分泌科/内分泌研究所;辽宁省内分泌疾病重点实验室,辽宁 沈阳 110001
通讯: 关 海霞 Email: hxguan@vip.126.com
DOI: 10.3978/.2018.05.015
基金: 辽宁省教育厅高等学校优秀人才支持计划资助项目(LJQ2015114);辽宁省科技厅重点研发计划指导计划资助项目(2017225008);辽宁省沈阳市中青年科技创新人才支持计划资助项目(RC170058)。

摘要

从众多甲状腺结节中正确鉴别出以分化型甲状腺癌(DTC)为主的甲状腺恶性肿瘤,是甲状腺结节术前评估的关键环节,也是减少诊断性手术、实现合理诊治DTC的第一步。分子诊断可能在其中发挥重要作用。笔者参考近5年文献,综述DTC术前分子诊断的研究进展,重点介绍其应用对象、效能评估以及可从商业化途径获得的分子诊断工具及其应用价值、卫生经济学考量和认识误区等。
关键词: 甲状腺肿瘤;甲状腺结节;分子诊断技术;综述文献

Preoperative molecular diagnosis of differentiated thyroid cancer: development status and future prospects

Authors: 1YU Yang, 1GUAN Haixia
1 Department of Endocrinology and Metabolism/Institute of Endocrinology, the First Affiliated Hospital, China Medical University; Liaoning Provincial Key Laboratory of Endocrine Diseases, Shenyang 110001, China

CorrespondingAuthor:GUAN Haixia Email: hxguan@vip.126.com

Abstract

Among numerous thyroid nodules, the accurate identification of differentiated thyroid cancer (DTC), which is the main type of thyroid malignancy, is a critical component in preoperative evaluation of thyroid nodules, and is also the first step toward reducing diagnostic surgery and realizing the proper management of DTC. The molecular diagnosis may play an important role in this process. Based on review of the literature of the last 5 years, the authors address the progress in the field of molecular diagnosis, with the emphasis on application population and diagnostic efficiency evaluation, as well as the commercially available molecular diagnostic tools together with their application values, considerations of health economics, and the misconceptions.
Keywords: Thyroid Neoplasms; Thyroid Nodule; Molecular Diagnostic Techniques; Review