文章摘要

微小RNA 在肝细胞癌中的相关研究进展

作者: 1房 锋, 1宋 天强
1 天津医科大学肿瘤医院 肝胆肿瘤科,天津 300060
通讯: 房 锋 Email: xyfangfeng@hotmail.com
DOI: 10.3978/.2018.07.015
基金: 国家自然科学基金资助项目( 81201644;81572858 )。

摘要

肝细胞癌是全球第五大常见恶性肿瘤,并高居全球癌症死因的第 3 位,现已成为严重威胁我国人民生命健康的重大恶性肿瘤之一。深入研究肝细胞癌发生发展过程中的分子机制,筛选与其紧密相关的核心分子,对于其预防、诊断和治疗具有十分重要的意义。微小 RNA(miRNA)是一类非编码调控RNA,miRNA 可调控人类 1/3 的基因表达,并参与了生命过程中的一系列重要进程,其在肿瘤发生发展中具有重要作用。笔者就 miRNA 在肝细胞癌中的表达、调控机制、生物学功能及临床应用前景等方面的研究进展行综述。
关键词: 癌,肝细胞;微 RNAs;综述文献

Research progress associated with microRNAs in hepatocellular carcinoma

Authors: 1Feng FANG, 1Tianqiang SONG
1 Department of Hepatobiliary Cancer, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, China

CorrespondingAuthor:Feng FANG Email: xyfangfeng@hotmail.com

Abstract

Hepatocellular carcinoma (HCC) is the fifth most common malignant tumor and the third of cancer related death worldwide, which has become one of the most common serious threats to people’s lives and health in China. Understanding the molecular mechanism for the occurrence and development of HCC is very important for its prevention, diagnosis and treatment. MicroRNAs (miRNAs) comprise a family of non-coding regulatory RNAs, and can regulate the expressions of 1/3 human genes. miRNAs participate in a series of important process, and play important roles in the pathogenesis of cancer. Here, the authors review the research progress about the expression, biological function and clinical applications of miRNAs in HCC.
Keywords: Carcinoma Hepatocellular; MicroRNAs; Review