基础研究(Basic Research)

突变型p53 与Nampt 在胃癌组织中的表达及其与预后的关系

Published at: 2015年第24卷第4期

李亮 1 , 陈锐 1 , 刘俊松 1 , 常帅 1 , 贺仕才 1 , 王泽星 1 , 王进 1 , 车向明 1 , 赵伟 1
1 西安交通大学第一附属医院 普通外科,陕西 西安 710061
通讯作者 伟 赵 Email: zhaowei9803@126.com
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2015.04.009
基金:
国家自然科学基金资助项目 81172357
陕西省科技攻关资助项目 2013SF2-03

摘要

目的:探讨突变型p53(mutp53)和尼克酰胺磷酸核糖转移酶(Nampt)在胃癌组织中的表达及其对患 者预后的影响。 方法:用免疫组化法检测68 例胃癌患者胃癌组织及癌旁正常胃黏膜组织中p53(免疫组化检测到的p53 主要为mutp53)与Nampt 的表达,分析mutp53 与Nampt 表达与患者临床病理因素及预后的关系。 结果:胃癌组织中mutp53 与Nampt 的阳性表达率均明显高于癌旁正常胃黏膜组织(均P<0.05); mutp53 的高表达与肿瘤大小、浸润深度、淋巴结转移及TNM 分期有关,而Nampt 的高表达与肿瘤浸 润深度、淋巴结转移及TNM 分期有关(均P<0.05)。胃癌组织中,p53 表达与Nampt 表达呈明显正相 关(r=0.982,P<0.05)。p53 阳性表达患者的中位生存期明显短于阴性表达患者,且在p53 阳性表达 患者中,Nampt 同时阳性患者的中位生存期明显短于Nampt 阴性患者(均P<0.05)。 结论:mutp53 与Nampt 的表达均与胃癌的恶性生物学行为相关,且两者存在一定的关联性,同时高表 达患者预后差。


Expressions of mutant p53 and Nampt in gastric cancer tissue and their relations with prognosis

Abstract

Objective: To investigate the expressions of mutant p53 (mutp53) and nicotinamide phosphoribosyltransferase (Nampt) in gastric cancer tissue and their influences on prognosis of the patients. Methods: Immunohistochemical staining was performed for detection of the expressions of p53 (immunohistochemical positive stained p53 proteins are mainly mutant type) and Nampt in specimens of gastric cancer tissues along with the adjacent normal gastric mucosa from 68 gastric cancer patients, and the relations of expression statuses of p53 and Nampt with the clinicopathologic factors and prognosis of the patients were analyzed. Results: The positive expression rates of p53 and Nampt in gastric cancer tissue were significantly higher than those in adjacent normal gastric mucosa (both P<0.05). The p53 overexpression was related to tumor size, infiltration depth, lymph node metastasis and TNM stage, while the Nampt overexpression was associated with infiltration depth, lymph node metastasis and TNM stage (all P<0.05). The expression of p53 was positively correlated with that of Nampt in gastric cancer tissue (r=0.982, P<0.05). The median survival time in patients with p53 positive expression was significantly shorter than that in patients with negative p53 expression; moreover, among patients with positive p53 expression, the median survival time in those with concomitant positive Nampt expression was significantly shorter than in those with negative Nampt expression (both P<0.05). Conclusion: Both mutp53 and Nampt expressions are related to the malignant behavior of gastric cancer, further, there is certain relevance between them, and patients with both mutp53 and Nampt overexpressions may face a poor prognosis.


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引用

引用本文: 亮 李, 锐 陈, 俊松 刘, 帅 常, 仕才 贺, 泽星 王, 进 王, 向明 车, 伟 赵. 突变型p53 与Nampt 在胃癌组织中的表达及其与预后的关系[J]. 中国普通外科杂志, 2015, 24(4): 505-510.
Cite this article as: LI Liang, CHEN Rui, LIU Junsong, CHANG Shuai, HE Shicai, WANG Zexing, WANG Jin, CHE Xiangming, ZHAO Wei . Expressions of mutant p53 and Nampt in gastric cancer tissue and their relations with prognosis [J]. Chin J Gen Surg, 2015, 24(4): 505-510.