肝肿瘤专题研究(Monographic Study of Hepatic Tumors)

射频消融治疗复发性肝癌的应用价值

Published at: 2015年第24卷第1期

刘绍平 1 , 罗汉传 1 , 林源 2 , 贺新新 1
1 广西医科大学第八附属医院 肝胆外科,广西 贵港 537100
2 广西医科大学附属肿瘤医院 胃肠外科,广西 南宁 530021
通讯作者 源 林 Email: gyly139@vip.sina.com
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2015.01.005
基金:

摘要

目的:评价经皮射频消融术(RFA)治疗复发性肝癌的疗效及安全性。 方法:回顾性分析2008 年5 月—2014 年3 月期间79 例行经皮RFA 治疗的肝癌复发患者临床资料, 79 例患者复发病灶共106 个,病灶大小0.8~5.0 cm,平均(2.8±1.0)cm。 结果:消融治疗成功率为98.1%,肿瘤完全消融率94.2%。术后常见不良反应为发热(72.7%)、肝区疼痛 (90.9%)、胃肠道症状(20.8%)、黄疸(6.5%),无肝功能衰竭、胆瘘、感染、出血等严重并发症,无 围手术期死亡病例。术后住院时间1~5 d,平均(2.2±1.0)d。术后随访7~64 个月,平均(38±14)个月, 54 例出现复发,复发率70.1%。术后1、3 年生存率分别为89.6%、66.2%。 结论:经皮RFA 治疗复发性小肝癌是一种安全有效的微创治疗方法,可优先考虑作为该病治疗的术式 选择。


Application value of radiofrequency ablation in treatment of recurrent hepatocellular carcinoma

Abstract

Objective: To assess the efficacy and safety of percutaneous radiofrequency ablation (RFA) in treatment of recurrent hepatocellular carcinoma (HCC). Methods: The clinical data of 79 patients with recurrent HCC undergoing percutaneous RFA from May 2008 to March 2014 were retrospectively analyzed. There were a total of 106 recurrent lesions in the 79 patients, and the tumor size ranged from 0.8 to 5.0 cm with an average of (2.8±1.0) cm. Results: The success rate of ablation was 98.1% and a complete tumor ablation rate reached 94.2%. The common post-ablation adverse reactions were fever (72.7%), pain in hepatic region (90.9%), gastrointestinal symptoms (20.8%), and jaundice (6.5%). No severe complications such as liver failure, bile leakage, infection, and bleeding occurred, and no perioperative death occurred as well. The length of postoperative hospital stay was 1 to 5 d with an average of (2.2±1.0) d. Follow-up was conducted for 7 to 64 months with an average of (38±14) months, post-ablation recurrence occurred in 54 cases, and the recurrence rate was 70.1%. The 1- and 3-year post-ablation survival rate was 89.6% and 66.2%, respectively. Conclusion: Percutaneous RFA is a safe, effective and minimally invasive treatment method for small recurrent HCC, and should be considered as a preferential alternative for this condition.


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引用

引用本文: 绍平 刘, 汉传 罗, 源 林, 新新 贺. 射频消融治疗复发性肝癌的应用价值[J]. 中国普通外科杂志, 2015, 24(1): 23–26.
Cite this article as: LIU Shaoping, LUO Hanchuan, LIN Yuan, HE Xinxin . Application value of radiofrequency ablation in treatment of recurrent hepatocellular carcinoma [J]. Chin J Gen Surg, 2015, 24(1): 23–26.