胃肿瘤专题研究(Monographic Study of Stomach Neoplasms)

IL-17 基因rs2275913 多态性与胃癌易感性的Meta 分析

Published at: 2015年第24卷第10期

鲁文君 1 , 王晓琴 1 , 杨丽霞 1 , 杨青 1 , 杨蓉 1 , 叶慧 1 , 俞登峰 1
1 甘肃省武威市肿瘤医院 肿瘤外科,甘肃 武威 733000
通讯作者 登峰 俞 Email: yudengfeng2015@163.com
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2015.10.003
基金:

摘要

目的:探讨IL-17 基因rs2275913 多态性与胃癌易感性的关系。方法:检索多个国内外数据库,收集有关IL-17 基因G>A 多态性位点rs2275913(G197A) 与胃癌易感性的病例- 对照研究。筛选文献、提取数据和文献质量评价后,采用STATA 12.1 统计软件进行Meta 分析。结果:最终纳入10 个病例- 对照研究,其中病例组4 371 例,对照组5 345 例。Meta 分析结果显示,IL-17 基因rs2275913 位点多态性的等位基因模型(A vs. G)(OR=1.22,95% CI=1.10~1.37)与相加模型(AA vs. GG)(OR=1.58,95% CI=1.23~2.04)胃癌风险增加,显性模型(AG+GG vs. AA)(OR=0.63,95% CI=0.48~0.84)、隐性模型(GG vs. AG+AA)(OR=0.86,95% CI=0.78~0.94)胃癌风险降低(均P<0.05),但共显性模型(AG vs. AA+GG)(OR=0.91,95% CI=0.78~1.07)与罹患胃癌的风险无明显关系(P>0.05)。结论:IL-17 基因rs2275913 多态性的与胃癌易感性密切相关。


Association between rs2275913 polymorphism in IL-17 gene and gastric cancer susceptibility: a Meta-analysis

Abstract

Objective: To investigate the association between rs2275913 site polymorphism of IL-17 gene and the risk of gastric cancer. Methods: The case-control studies on relationship between the IL-17 rs2275913 G>A polymorphism and gastric cancer susceptibility were collected by searching several national and international databases. After literature screening, data extraction and quality assessment, Meta-analysis was performed by STATA 12.1 software. Results: Ten case-control studies were finally included, with 4 371 patients in case group and 5 345 subjects in control group. Meta-analysis results showed that among the rs2275913 site polymorphisms of IL-17 gene, the risk of gastric cancer was increased under allele-contrast model (A vs. G) (OR=1.22, 95% CI=1.10–1.37) and additive model (AA vs. GG) (OR=1.58, 95% CI=1.23–2.04), and was decreased under dominant model (AG+GG vs. AA) (OR=0.63, 95% CI=0.48–0.84) and recessive model (GG vs. AG+AA) (OR=0.86, 95% CI=0.78–0.94), but had no obvious change under codominant model (AG vs. AA+GG) (OR=0.91, 95% CI=0.78–1.07). Conclusion: IL-17 rs2275913 polymorphism is closely related to gastric cancer susceptibility.


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引用本文: 文君 鲁, 晓琴 王, 丽霞 杨, 青 杨, 蓉 杨, 慧 叶, 登峰 俞. IL-17 基因rs2275913 多态性与胃癌易感性的Meta 分析[J]. 中国普通外科杂志, 2015, 24(10): 1356-1362.
Cite this article as: LU Wenjun, WANG Xiaoqin, YANG Lixia, YANG Qing, YANG Rong, YE Hui, YU Dengfeng . Association between rs2275913 polymorphism in IL-17 gene and gastric cancer susceptibility: a Meta-analysis[J]. Chin J Gen Surg, 2015, 24(10): 1356-1362.