胃肿瘤专题研究(Monographic Study of Stomach Neoplasms)

胃癌患者ABO 血型与临床病理特征关系

Published at: 2015年第24卷第10期

郭忠武 1 , 薛英威 1
1 哈尔滨医科大学附属肿瘤医院 胃肠外科, 黑龙江 哈尔滨 150081
通讯作者 英威 薛 Email: xyw801@163.com
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2015.10.005
基金:

摘要

目的:探讨胃癌患者ABO 血型分布特点及其与胃癌发病的关系。方法:回顾性分析哈尔滨医科大学附属肿瘤医院2010—2011 年期间1 744 例胃癌患者临床病理资料,分析其ABO 血型分布与正常人群(496 447 例)ABO 血型分布的差异;并分析其临床病理特征的关系。结果:1 744 例胃癌患者中,A 型患者554 例(31.77%),B 型524 例(30.05%),O 型468 例(26.83%),AB 型198 例(11.35%)。胃癌患者ABO 血型分布与正常人群ABO 血型分布比较有统计学差异(χ2=38.384,P=0.000);A 型较非A 型胃癌发生风险升高(OR=1.174,95% CI=1.061~1.299),AB 型较非AB 型胃癌发生风险升高(OR=1.282,95% CI=1.106~1.487),O 型较非O 型胃癌发生风险下降(OR=0.738,95% CI=0.664~0.821)。B 型胃癌累及部位分布与O 型间有明显差异(P<0.05);A 型较B 型淋巴结转移率高(72.77% vs. 65.57%,P<0.05);A 型与O 型较AB 型远处转移率高(16.02% vs. 9.14%;15.25% vs. 9.14%,均P<0.05)。结论:胃癌患者ABO 血型分布与正常人群ABO 血型分布有差别,A、AB 型人群较其它血型人群胃癌发生风险升高,而O 型胃癌发生风险减低,血型可能是胃癌发生的风险因素之一,且胃癌生物学行为有关。


Relations of ABO blood group with clinicopathologic features of patients with gastric cancer

Abstract

Objective: To investigate the distribution profiles of the ABO blood group in gastric cancer patients and their relations with the occurrence of gastric cancer. Methods: The clinicopathologic data of 1 744 gastric cancer patients treated in Cancer Hospital affiliated to Harbin Medical University during 2010 to 2011 were retrospectively analyzed. The difference of distribution patterns of ABO blood types between gastric cancer patients and healthy population (496 447 cases) was compared, and the relations of blood types with clinicopathologic features of gastric cancer patients were determined. Results: Of the 1 744 gastric cancer patients, 554 cases (31.77%) were A blood type, 524 cases (30.05%) were B blood type, 468 cases (26.83%) were O blood type, and 198 cases (11.35%) were AB blood type, respectively. The distribution of ABO blood types in gastric cancer patients was statistically different to that in healthy population (χ2=38.384, P=0.000); the risk of gastric cancer in cases with A blood type was higher than in non-A individuals (OR=1.174, 95% CI=1.061–1.299), in cases with AB blood type was higher than that in non-AB individuals (OR=1.282, 95% CI=1.106–1.487), while in those with O blood type was lower than that in non-O individuals (OR=0.738, 95% CI=0.664–0.821). There was significant difference in tumor location between patients with O and B blood type (P<0.05), lymph node metastasis in patients with A blood type was higher than that in those with B blood type (72.77% vs. 65.57%, P<0.05), and distant metastasis of in patients with blood type A or O was higher than that in those with blood type AB (16.02% vs. 9.14%; 15.25% vs. 9.14%, both P<0.05). Conclusion: The distribution of ABO blood types in gastric cancer patients is different from that in healthy population. The risk of gastric cancer may increase in individuals with A or AB blood type, but decrease in those with O blood type, and blood types might be one of the risk factors for gastric cancer, and also be associated with the biological behavior of gastric cancer.


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引用

引用本文: 忠武 郭, 英威 薛. 胃癌患者ABO 血型与临床病理特征关系[J]. 中国普通外科杂志, 2015, 24(10): 1367-1371.
Cite this article as: GUO Zhongwu, XUE Yingwei . Relations of ABO blood group with clinicopathologic features of patients with gastric cancer[J]. Chin J Gen Surg, 2015, 24(10): 1367-1371.