基础研究(Basic Research)

自噬相关蛋白Beclin 1 在胃癌组织中表达意义的Meta 分析

Published at: 2015年第24卷第10期

余招焱 1 , 丁杰 1 , 杨晓飞 1 , 张忠民 1
1 贵州省人民医院 普通外科,贵州 贵阳 550002
通讯作者 招焱 余 Email: zhaoyan.yu@sohu.com
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2015.10.009
基金:
贵州省科学技术博士基金资助项目 [2015]2095
贵州省科学技术厅联合基金资助项目 [2014]7011

摘要

目的:系统评价胃癌组织中自噬相关蛋白Beclin 1(BECN1)的表达及其与胃癌患者临床病理特征之间的相关性。方法:检索国内外相关数据库,收集2015 年2 月1 日前发表的关于胃癌组织中BECN1 的表达及其临床意义的研究,提取相关数据,采用RevMan 5.3 及Stata12.0 软件进行Meta 分析。结果:最终纳入了9 个研究,其中包含胃癌患者1 620 例。Meta 分析结果显示,胃癌组织中BECN1的表达阳性率明显低于非胃癌组织(OR=0.11,95% CI=0.02~0.62,P=0.01); 高分化胃癌组织的BECN1 表达阳性率明显高于中低分化胃癌组织(OR=14.30,95% CI=5.94~34.4,P=0.000);无远处转移患者的胃癌组织中BECN1 表达阳性率明显高于有远处转移者(OR=0.39,95% CI=0.22~0.70,P=0.001);BECN1 表达与胃癌患者性别、年龄、肿瘤浸润深度、淋巴结转移及TNM 分期等无关(均P>0.05)。结论:BECN1 在胃癌的发生和胃癌细胞分化中可能起重要作用,且BECN1 可能参与了胃癌细胞转移能力的调控。


Significance of autophagy-related protein beclin 1 expression in gastric cancer: a Meta-analysis

Abstract

Objective: To systematically analyze the expression of autophagy-related protein Beclin 1 (BECN1) in gastric cancer tissue and the correlation between BECN1 expression and clinicopathologic features of gastric cancer patients. Methods: The studies investigating BECN1 expression in gastric cancer tissues and its clinical significance published up to February 2015 were collected by searching the national and international databases. After data extraction, a meta-analysis was performed by using RevMan 5.3 and Stata12.0 software. Results: Nine studies were finally included, involving 1 620 gastric cancer patients. The results of this metaanalysis showed that the positive expression rate of BECN1 in gastric cancer tissues was significantly lower than that in non-gastric cancer tissues (OR=0.11, 95% CI=0.02–0.62, P=0.01), in well differentiated gastric cancer tissues was significantly higher than that in moderately-poorly differentiated gastric cancer tissues (OR=14.30, 95% CI=5.94–34.4, P=0.000), and in gastric cancer tissues without distant metastasis was significantly higher than that in those with distant metastasis (OR=0.39, 95% CI=0.22–0.70, P=0.001), but no significant relationship was noted between BECN1 expression and gender, age, tumor infiltration depth, lymph node metastasis and TNM stage of gastric cancer patients (all P>0.05). Conclusion: BECN1 may play a crucial role in gastric cancer carcinogenesis and differentiation of gastric cancer cells, and may also participate in the regulation of the metastasis ability of gastric cancer cells.


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引用

引用本文: 招焱 余, 杰 丁, 晓飞 杨, 忠民 张. 自噬相关蛋白Beclin 1 在胃癌组织中表达意义的Meta 分析[J]. 中国普通外科杂志, 2015, 24(10): 1389-1395.
Cite this article as: YU Zhaoyan, DING Jie, YANG Xiaofei, ZHANG Zhongmin . Significance of autophagy-related protein beclin 1 expression in gastric cancer: a Meta-analysis[J]. Chin J Gen Surg, 2015, 24(10): 1389-1395.