microRNA（miRNA）是一类内源性非编码RNA，它参与癌症发生发展过程中多个通路的调控。肝细 胞癌（HCC）是最常见的恶性肿瘤之一，目前缺乏有效的治疗手段，预后较差。研究表明，miR-122 在HCC 的发生发展中起着重要的抑制作用，它可能成为新的HCC 诊断和预后的重要生物标记以及治 疗靶点。笔者就miR-122 与HCC 的关系研究进展进行综述。
Research progress of miRNA-122 and hepatocellular carcinoma
MicroRNAs (miRNAs) are endogenous non-coding RNAs, participating in diverse pathways that regulate tumor occurrence and progression. Hepatocellular carcinoma (HCC) is one of the most common malignancies, with poor prognosis due to lack of effective treatment modalities at present. Studies have showed that miR-122 plays an important suppressive role in genesis and progression of HCC, so it may probably become a novel biomarker for diagnosis and prognosis as well as therapeutic target of HCC. Here, the authors present the research progress in relationship between miR-122 and HCC.