甲状腺肿瘤专题研究(Monographic Study of Thyroid Surgery)

甲状腺癌患者外周血CEACAM1 水平及其临床意义

Published at: 2015年第24卷第11期

赵丹 1 , 张宇 2
1 河南省南阳医学高等专科学校第一附属医院 重症医学科,河南 南阳 473000
2 河南省郑州市人民医院 普外五科,河南 郑州 450003
通讯作者 丹 赵 Email: 55782272@qq.com
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2015.11.006
基金:

摘要

目的:探讨癌胚抗原黏附分子1(CEACAM1)在甲状腺癌患者外周血中水平及其对甲状腺癌的诊断价值。方法:用ELISA 法检测76 例甲状腺癌患者、48 例甲状腺良性肿瘤患者和38 例健康体检者外周血中CEACAM1 水平,同时检测所有入组样本的癌胚抗原(CEA)及甲状腺球蛋白(TG)水平,分析外周血CEACAM1 水平与甲状腺癌临床病理特征的关系,制作ROC 曲线,比较CEACAM1、CEA、TG 对甲状腺癌的诊断价值。结果:甲状腺癌患者血清CEACAM1 水平明显高于甲状腺良性肿瘤患者及健康对照者(547.11 ng/mL vs.469.77 ng/mL、369.04 ng/mL,均P<0.05)。血清CEACAM1 水平与甲状腺癌的TNM 分期和淋巴结转移有关(均P<0.05)。血清CEACAM1 水平诊断甲状腺癌的ROC 曲线下面积为0.94,敏感性97.4%,特异性80.3%,CEACAM1 对甲状腺癌的诊断价值优于CEA 和TG。结论:血清CEACAM1 检测对甲状腺癌的诊断及其病情评估有一定意义。


Peripheral blood level of CEACAM1 in patients with thyroid cancer and its clinical significance

Abstract

Objective: To investigate the peripheral blood level of carcinoembryonic antigen-related cell adhesion molecular 1 (CEACAM1) in patients with thyroid cancer and its diagnostic value for thyroid cancer. Methods: Using ELISA assay, the serum CEACAM1 levels in 76 thyroid cancer patients, 48 patient with benign thyroid tumor and 38 healthy subjects were determined, and meanwhile, the levels of carcinoembryonic antigen (CEA) and thyroglobulin (TG) were also measured. The relations of CEACAM1 level with clinicopathologic characteristics of thyroid cancer were analyzed. Through drawing ROC curves, the diagnostic values for thyroid cancer among CEACAM1, CEA and TG were compared. Results: The serum CEACAM1 level in thyroid cancer patients was significantly higher than that in patients with benign thyroid tumor or healthy control individuals (547.11 ng/mL vs. 469.77 ng/mL and 369.04 ng/mL, both P<0.05). The serum CEACAM1 level was significantly associated with TNM stage and lymph node metastasis of thyroid cancer patients (both P<0.05). The area under the ROC curve of CEACAM1 for diagnosis of thyroid cancer was 0.94, with sensitivity of 97.4% and specificity of 80.3%, and the diagnostic value of CEACAM1 for thyroid cancer was superior to that of CEA or TG. Conclusion: Serum CEACAM1 detection has certain value for diagnosis and disease assessment of thyroid cancer.


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引用

引用本文: 丹 赵, 宇 张. 甲状腺癌患者外周血CEACAM1 水平及其临床意义[J]. 中国普通外科杂志, 2015, 24(11): 1525-1529.
Cite this article as: ZHAO Dan, ZHANG Yu . Peripheral blood level of CEACAM1 in patients with thyroid cancer and its clinical significance[J]. Chin J Gen Surg, 2015, 24(11): 1525-1529.