乳腺肿瘤专题研究(Monographic Study of Breast Tumors)

乳腺癌患者外周血中T 细胞亚群与淋巴结转移和组织学分级的关系

Published at: 2015年第24卷第11期

曾繁余 1 , 彭德珍 2 , 张珊 1 , 唐巍 1 , 张秋瑾 3 , 刘文慧 3 , 骆耐香 3
1 桂林医学院附属医院普外二科,广西 桂林 541001
2 桂林医学院附属医院检验科,广西 桂林 541001
3 桂林医学院 免疫学教研室, 广西 桂林 541004
通讯作者 耐香 骆 Email: luonaixiang@163.com
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2015.11.012
基金:
国家自然科学基金资助项目 81260317
广西壮族自治区卫生厅基金资助项目 Z2013469
桂林市科学技术 局科技攻关基金资助项目 20140120-1-10

摘要

目的:探讨乳腺癌患者外周血中T 细胞亚群的变化及其与淋巴结转移和组织学分级的关系。方法:用流式细胞术检测86 例乳腺癌患者以及20 例乳腺腺病患者外周血T 细胞亚群的百分率。结果:乳腺癌患者外周血总T 细胞与CD4+T 细胞百分数与腺病患者无统计学差异(均P>0.05),但CD8+T 细胞百分数低于腺病患者(P<0.05)。乳腺癌患者中,淋巴结转移者CD4+T 细胞百分数高于无淋巴结转移者(P<0.05);CD8+T 细胞百分数随组织学分级增加而升高(P<0.05)。结论:乳腺癌患者存在细胞免疫功能紊乱,外周血中CD4+T 细胞、CD8+T 细胞比例的变化分别与淋巴结转移、组织学分级密切相关。监测外周血T 细胞亚群的变化,有助于病情及预后的判断。


Relations of peripheral blood T cell subsets with lymph node metastasis and histological grade in breast cancer patients

Abstract

Objective: To investigate the alterations of peripheral blood T cell subsets and their relations with lymph node metastasis and histological grade in breast cancer patients. Methods: The percentages of T cell subsets in peripheral blood in 86 patients with breast cancer and 20 patients with mammary adenosis were determined by flow cytometry. Results: There was no significant difference in percentages of peripheral blood total T cells and CD4+ T cells between breast cancer patients and mammary adenosis patients (both P>0.05), but the percentage of peripheral blood CD8+ T cells in breast cancer patients was lower than that of mammary adenosis patients (P<0.05). In breast cancer patients, the percentage of CD4+ T cells in cases with lymph node metastasis was higher than that of cases without lymph node metastasis (P<0.05); the percentage of CD8+ T cells was increased with histological grade increase (P<0.05). Conclusion: There are cell-mediated immune disorders in breast cancer patients, and the alteration in proportion of CD4+ T cells and CD8+ T cells in peripheral blood is closely related to lymph node metastasis and tumor histological grade, respectively. Monitoring of the alterations in peripheral blood T cell subsets may be helpful for estimation of the disease status and prognosis.


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引用

引用本文: 繁余 曾, 德珍 彭, 珊 张, 巍 唐, 秋瑾 张, 文慧 刘, 耐香 骆. 乳腺癌患者外周血中T 细胞亚群与淋巴结转移和组织学分级的关系[J]. 中国普通外科杂志, 2015, 24(11): 1559-1564.
Cite this article as: ZENG Fanyu, PENG Dezhen, ZHANG Shan, TANG Wei, ZHANG Qiujin, LIU Wenhui, LUO Naixiang . Relations of peripheral blood T cell subsets with lymph node metastasis and histological grade in breast cancer patients[J]. Chin J Gen Surg, 2015, 24(11): 1559-1564.