乳腺肿瘤专题研究(Monographic Study of Breast Tumors)

常规处理方案联合铜绿假单胞菌制剂治疗乳腺癌疗效的Meta 分析

Published at: 2015年第24卷第5期

郭智慧 1 , 罗道蕴 2 , 周庆 1 , 杨志明 2
1 成都医学院第一附属医院甲乳外科,四川 成都 610500
2 成都医学院第一附属医院肝胆外科,四川 成都 610500
通讯作者 道蕴 罗 Email: 1328704915@qq.com
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2015.05.011
基金:

摘要

目的:系统性评价铜绿假单胞菌制剂应用于乳腺癌治疗中的效果。方法:检索国内外数据库,检索时间为各数据库建库至2014 年11 月。纳入在乳腺癌治疗中应用铜绿假单胞菌制剂的随机对照试验(RCT),筛选文献、提取数据和文献质量评价后,用RevMan 5.1.2 软件进行Meta 分析。结果:共纳入9 篇RCT 研究,Meta 分析结果显示,常规处理方案联合铜绿假单胞菌制剂明显升高患者完全缓解率(OR=2.22)、总有效率(OR=6.73)、患者Karnofsky 评分(MD=9.79) 及IL-2 水平(SMD=1.56),明显降低患者疾病稳定率(OR=0.36)、疾病进展率(OR=0.18)以及缩短患者术后积液消失时间(MD=-7.52)。结论:联合铜绿假单胞菌制剂可明显提高乳腺癌患者放化疗效果,但该结论仍需要高质量的研究进一步证实。


Efficacy of conventional therapy combined with use of pseudomonas aeruginosa preparation for treatment of breast cancer: a Meta-analysis

Abstract

Objective: To systematically evaluate the efficacy of use of pseudomonas aeruginosa (PA) preparation in treatment of breast cancer. Methods: The randomized controlled trials (RCTs) concerning the use of PA preparation in treatment of breast cancer were collected by searching the national and international databases, and the time period of search ranged from inception of each database until November 2014. After literature screening, data extraction and quality assessment, Meta-analysis was performed by Revman 5.1.2 software. Results: Nine RCTs were finally included. The results of Meta-analysis showed that combined use of PA preparation with conventional treatment significantly increased the complete response rate (OR=2.22), total response rate (OR=6.73), Karnofsky score (MD=9.79) and IL-2 level, and significantly decreased the stable disease rate (OR=0.36) and progress disease rate (OR=0.18), as well as shortened the time to disappearance of the postoperative fluid collection (MD=–7.52). Conclusion: Combined use of PA preparation can increase the efficacy of conventional chemoradiotherapy in treatment of breast cancer, but this conclusion needs further verification by more high quality studies.


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引用本文: 智慧 郭, 道蕴 罗, 庆 周, 志明 杨. 常规处理方案联合铜绿假单胞菌制剂治疗乳腺癌疗效的Meta 分析[J]. 中国普通外科杂志, 2015, 24(5): 669-676.
Cite this article as: GUO Zhihui, LUO Daoyun, ZHOU Qing, YANG Zhiming . Efficacy of conventional therapy combined with use of pseudomonas aeruginosa preparation for treatment of breast cancer: a Meta-analysis[J]. Chin J Gen Surg, 2015, 24(5): 669-676.