基础研究(Basic Research)

基底细胞样乳腺癌中HIF-1α 及Glut-1 的表达及意义

Published at: 2015年第24卷第5期

周炳娟 1 , 陈红 1 , 马秋双 1 , 张金库 1 , 张楠 1 , 肖士卿 1 , 王国茹 2 , 马红普 3
1 河北省保定市第一中心医院 病理科,河北 保定 071000
2 河北省容城县医院 妇产科,河北 保定 071700
3 河北省高阳县医院 妇产科,河北 保定 071500
通讯作者 金库 张 Email: zjkblk@sohu.com
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2015.05.019
基金:

摘要

目的:探讨缺氧诱导因子1α(HIF-1α)及葡萄糖转运蛋白1(Glut-1)蛋白在基底细胞样乳腺癌(BLBC)中的表达及临床意义。方法: 采用免疫组化方法检测95 例BLBC 及其癌旁乳腺组织与708 例非BLBC 组织中HIF-1α 及Glut-1 蛋白的表达,分析两者表达与BLBC 临床病理因素的关系。结果:HIF-1α 及Glut-1 蛋白在BLBC 组织的阳性表达率均明显高于癌旁组织与非BLBC 组织(均P<0.05),两种蛋白的表达呈明显正相关(r=0.368,P<0.05)。结论:HIF-1α 和Glut-1 的表达在BLBC 组织中同时升高,两者可能共同参与了BLBC 的发生、发展,并可能作为评估BLBC 患者预后的指标。


Expression and significance of HIF-1α and Glut-1 in basal-like breast carcinoma

Abstract

Objective: To investigate the expression and clinical significance of hypoxia inducible factors 1α (HIF-1α) and glucose transporter 1 (Glut-1) in basal-like breast carcinoma (BLBC). Methods: The protein expressions of HIF-1α and Glut-1 in 95 specimens of BLBC and their adjacent breast tissue, and 708 samples of non-BLBC tissue were detected by immunohistochemical staining, and their relations with the clinicopathologic factors of BLBC were analyzed. Results: The positive expression rate of either HIF-1α or Glut-1 protein in BLBC tissue was significantly higher than that in adjacent breast tissue and non-BLBC tissue (all P<0.05), and both HIF-1α and Glut- 1 protein expressions were associated with lymph node metastasis and clinical stage of BLBC (all P<0.05); there was a significantly positive correlation between HIF-1α and Glut-1 expression in BLBC tissue (r=0.368, P<0.05). Conclusion: HIF-1α and Glut-1 synchronously overexpress in BLBC tissue, which may co-participate in the occurrence and development of BLBC, and can be potentially used as a prognostic index for BLBC patients.


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引用

引用本文: 炳娟 周, 红 陈, 秋双 马, 金库 张, 楠 张, 士卿 肖, 国茹 王, 红普 马. 基底细胞样乳腺癌中HIF-1α 及Glut-1 的表达及意义[J]. 中国普通外科杂志, 2015, 24(5): 712-716.
Cite this article as: ZHOU Bingjuan, CHEN Hong, MA Qiushuang, ZHANG Jinku, ZHANG Nan, XIAO Shiqing, WANG Guoru, MA Hongpu . Expression and significance of HIF-1α and Glut-1 in basal-like breast carcinoma[J]. Chin J Gen Surg, 2015, 24(5): 712-716.