专题研究(Monographic Study)

非接触分离技术在原发性肝细胞癌手术治疗中的应用

Published at: 2016年第25卷第1期

曹堃 1 , 马金良 1 , 许戈良 1 , 荚卫东 1 , 刘文斌 1 , 张传海 1
1 安徽医科大学附属省立医院 肝脏外科/ 肝胆胰外科安徽省重点实验室,安徽 合肥 230001
通讯作者 金良 马 Email: majlwq@163.com
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2016.01.005
基金:
安徽省2011 年度科技计划资助项目 11010402163

摘要

目的:探讨原发性肝细胞癌应用非接触分离技术切除的临床效果效。方法:回顾性分析2011 年1 月—2013 年1 月70 例应用非接触分离技术行手术切除的原发性肝细胞癌患者(观察组),以及同期70 例行传统手术方式切除的原发性肝细胞癌患者(对照组)临床资料,比较两组相关手术指标及术后发率、生存情况。结果: 与对照组比较, 观察组手术时间有所延长[(238.9±44.8)min vs.(132.8±25.4)min,P<0.05]、术中出血量及输血率差异无统计学意义[(461.0±112.6)mL vs.(464.6+109.0)mL;31.4% vs. 28.5%,均P>0.05]、肝门阻断率降低(7.14% vs. 32.9%,P<0.05);两组的并发症发生率差异无统计学意义(18.6% vs. 22.9%,P>0.05);观察组1 年复发率明显低于对照组(24.3% vs. 44.3%,P<0.05),但1 年生存率两组无统计学差异(88.6% vs. 81.2%,P>0.05)。结论:非接触分离技术用于原发性肝细胞癌手术治疗对于减少术后肿瘤复发有着积极的作用,较传统手术方式有一定优势。


Application of “no-touch” isolation technique in surgical treatment of hepatocellular carcinoma

Abstract

Objective: To assess the clinical effect of using “no-touch” isolation technique in surgical treatment of hepatocellular carcinoma (HCC). Methods: The clinical data of 70 HCC patients undergoing surgical resection with “no-touch” isolation technique (observational group) from January 2011 to January 2013, and 70 HCC patients undergoing conventional resection technique (control group) during the same period were retrospectively analyzed. The relevant surgical variables as well as the postoperative recurrence and survival between the two groups were compared. Results: In observational group compared with control group, the operative time was prolonged [(238.9± 44.8) min vs. (132.8±25.4) min, P<0.05], both intraoperative blood loss and blood transfusion rate showed no statistical difference [(461.0±112.6) mL vs. (464.6±109.0) mL; 31.4% vs. 28.5%, both P>0.05], and the hepatic portal occlusion rate was decreased (7.14% vs. 32.9%, P<0.05). No significant difference was noted in incidence of postoperative complications between the two groups (18.6% vs. 22.9%, P>0.05). The 1-year recurrence rate in observational group was significantly lower than that in control group (24.3% vs.44.3%, P<0.05), but the 1-year survival rate of the two groups had no statistical difference (88.6% vs. 81.2%, P>0.05). Conclusion: Using “no-touch” isolation technique in HCC surgical treatment may provide an active support for reducing postoperative tumor recurrence, and it has certain superiority to conventional technique.


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引用

引用本文: 堃 曹, 金良 马, 戈良 许, 卫东 荚, 文斌 刘, 传海 张. 非接触分离技术在原发性肝细胞癌手术治疗中的应用[J]. 中国普通外科杂志, 2016, 25(1): 25-31.
Cite this article as: CAO Kun, MA Jinliang, XU Geliang, JIA Weidong, LIU Wenbin, ZHANG Chuanhai . Application of “no-touch” isolation technique in surgical treatment of hepatocellular carcinoma[J]. Chin J Gen Surg, 2016, 25(1): 25-31.