目的：总结始发症状为急性胰腺炎（AP）的胰腺占位性病变的临床特点，以期为今后该类情况的诊治提供借鉴。方法： 收集内蒙古医科大学附属医院于2010 年9 月—2014 年10 月收治的12 例典型上述病例资料，对其临床表现、实验室指标、影像学特点等多项参数进行综合分析。结果：12 例患者均诊断为AP 入院；男女性别比列为11:1，明显高于胰腺癌发病的性别比（1.4:1）；12例（100%）尿淀粉酶均显著增高（>1 500 IU/L），伴明显腰部放射痛8 例（66.7%），CA19-9 升高6例（50.0%）；胆红素增高6 例（50.0%），胰管扩张7 例（58.3%）；5 例获根治性手术，其余因失去根治手术机会行非手术或姑息手术治疗，其中1 例（8.3%）姑息手术术后病理确诊慢性胰腺炎。结论：在AP 患者中，男性患者、尿淀粉酶持续增高、伴有腰部放射痛、轻度胰管扩张、黄疸持续不退等对胰腺占位病变的诊断有提示作用。
Diagnosis and treatment of pancreatic occupying lesions with initial presentation of acute pancreatitis: an analysis of 12 cases
Objective: To review the clinical characteristics of pancreatic occupying lesions with initial presentation of acute pancreatitis (AP), for providing warnings of this condition. Methods: The data of 12 typical cases with above condition admitted between September 2010 and October 2014 were collected, and variables such as clinical findings, laboratory parameters and imaging features were comprehensively analyzed. Results: All of the 12 patients were admitted for AP; the male to female ratio was 11:1, which was remarkably higher than that (1.4:1) of pancreatic cancer. The urine amylase was markedly increased (>1 500 U/L) in all cases (100%), 8 cases (66.7%) were accompanied with evident radiating pain around the waist, 6 cases (50.0%) showed increased CA19-9 level, 6 cases (50.0%) had elevated serum bilirubin level and pancreatic duct dilation was found in 7 cases (58.3%). Five cases underwent radical surgery, and the other cases had non-surgical treatment or palliative operation due to loss of chance for radical surgery, and one of the cases (8.3%) undergoing palliative operation was pathologically proven to be chronic pancreatitis after operation. Conclusion: Among the AP patients, pancreatic occupying lesions should be taken into consideration in those with factors that include male sex, increased urine amylase, pancreatic duct dilation, and accompanied with pain radiating around the waist and persistent jaundice.