临床研究(Clinical Research)

原发性乳腺淋巴瘤8例临床病理分析并文献复习

Published at: 2016年第25卷第5期

邵云 1 , 吴永芳 1 , 张博 1 , 许春伟 1 , 王怀涛 1 , 李晓兵 1
1 中国人民解放军军事医学科学院附属医院 病理科,北京 100071
通讯作者 云 邵 Email: shysep@163.com
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2016.05.017
基金:

摘要

目的:探讨乳腺淋巴瘤的临床病理学特点及诊断要点。方法:收集2009年1月—2015年3月确诊为乳腺淋巴瘤的病例资料,进行临床资料、病理形态学及免疫组化分析,并结合文献对该病的诊断及鉴别诊断进行讨论。结果:8例均为女性,发病年龄35~82岁,6例位于左乳,1例右侧,1例双侧。多数表现为无痛性肿块,边界较清,可活动。7例为弥漫大B细胞淋巴瘤(DLBCL),1例为黏膜相关淋巴组织淋巴瘤(MALT),免疫组化染色均表达CD20、CD79a,7例MUM1阳性,4例Bcl-2阳性。治疗后4例患者获随访3~25个月,均健在。结论:乳腺淋巴瘤少见,常见类型为DLBCL,确诊依赖组织病理学和免疫组化染色。提高对乳腺淋巴瘤的认识,对避免误诊是至关重要的。


Primary breast lymphoma: a clinicopathologic analysis of 8 cases and literature review

Abstract

Objective: To investigate the clinicopathologic characteristics and diagnostic criteria of primary breast lymphoma (PBL). Methods: The cases diagnosed as PBL from January 2009 to March 2015 were collected, their clinical data, and pathological and immunohistochemical features were analyzed, and the diagnosis and differential diagnosis of this condition were discussed with a literature review. Results: All the 8 cases were female, and age of onset ranged from 35 to 82 years. The tumor was located in left breast in 6 cases, in right breast in one case, and in both breasts in one case. The most common presentation was painless mobile mass with distinct borders. Seven cases were diagnosed as diffuse large B-cell lymphoma (DLBCL), and one was diagnosed as mucosa-associated lymphoid tissue lymphoma (MALT). Immunohistochemical staining showed that CD20 and CD79a positive expressions were found in all cases, 7 cases had mum-1 positive expression and 4 cases had Bcl-2 positive expression. After treatment, 4 patients were followed up for 3 to 25 months and all were alive. Conclusion: PBL is a rare condition, and DLBCL is the most common type. Its diagnosis depends on pathological and immunohistochemical examinations. Full awareness of this entity is important for avoiding misdiagnosis.


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引用

引用本文: 云 邵, 永芳 吴, 博 张, 春伟 许, 怀涛 王, 晓兵 李. 原发性乳腺淋巴瘤8例临床病理分析并文献复习[J]. 中国普通外科杂志, 2016, 25(5): 724-728.
Cite this article as: SHAO Yun, WU Yongfang, ZHANG Bo, XU Chunwei, WANG Huaitao, LI Xiaobing . Primary breast lymphoma: a clinicopathologic analysis of 8 cases and literature review [J]. Chin J Gen Surg, 2016, 25(5): 724-728.