基础研究(Basic Research)

配对相关同源框-1蛋白在胆囊癌组织中的表达及意义

Published at: 2017年第26卷第2期

白明辉 1 , 刘海潮 1
1 郑州大学附属洛阳中心医院 肝胆疝外科二病区,河南 洛阳 471009
通讯作者 明辉 白 Email: bmh96290@163.com
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2017.02.009
基金:

摘要

目的:探讨配对相关同源框-1蛋白(Prrx-1)在胆囊癌组织中的表达及意义。方法:用免疫组化方法测定Prrx-1在45例胆囊癌及35例胆囊良性病变组织中的表达情况,并分析Prrx-1和胆囊癌临床病理特征之间的关系。结果:Prrx-1在胆囊癌组织中表达率为55.6%(25/45),而在胆囊良性病变组织中的表达率 5.7%(2/35),两者差异有统计学意义(χ2=21.87,P<0.05)。统计分析显示,Prrx-1表达与胆囊癌的组织分化程度、临床分期有关(P<0.05),而与胆囊癌患者的年龄、性别及胆囊癌的组织学类型无关(均P>0.05)。结论:Prrx-1在胆囊癌组织中表达增高,其表达可能在胆囊癌的发生、发展中起重要作用。


Expression and significance of paired-related homeobox 1 protein in gallbladder carcinoma tissue

Abstract

Objective: To investigate the expression of paired-related homeobox 1 protein (Prrx-1) in gallbladder cancer tissue and its significance. Methods: The Prrx-1 expressions in 45 specimens of gallbladder cancer tissues and 35 specimens of gallbladder tissues with benign diseases were determined by immunohistochemical staining, and the relations of Prrx-1 expression with clinicopathologic profiles of gallbladder cancer were analyzed. Results: The expression rate of Prrx-1 was 55.6% (25/45) in gallbladder cancer tissue, and was 5.7% (2/35) in gallbladder tissue with benign diseases, and the difference between them had statistical significance (χ2=21.87, P<0.05). Statistical analysis indicated that the Prrx-1 expression was closely associated with the degree of differentiation and clinical stage of gallbladder cancer (both P<0.05), but irrelevant to the sex and age of the patients and histological type of gallbladder cancer (all P>0.05). Conclusion: Prrx-1 expression is increased in gallbladder cancer and its expression may be closely connected to the occurrence and development of gallbladder cancer.


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引用

引用本文: 明辉 白, 海潮 刘. 配对相关同源框-1蛋白在胆囊癌组织中的表达及意义[J]. 中国普通外科杂志, 2017, 26(2): 185-189.
Cite this article as: BAI Minghui, LIU Haichao . Expression and significance of paired-related homeobox 1 protein in gallbladder carcinoma tissue[J]. Chin J Gen Surg, 2017, 26(2): 185-189.