临床研究(Clinical Research)

下腔静脉隔膜阻塞型Budd-Chiari 综合征血流数值模拟

Published at: 2015年第24卷第6期

庄银苹 1 , 王权 2 , 侯琳 1 , 张彬 1 , 周思远 1 , 王阿明 1 , 祖茂衡 3
1 徐州医学院 医学影像学院,江苏 徐州 221002
2 徐州医学院第二附属医院 影像科,江苏 徐州 221002
3 徐州医学院附属医院 介入放射科,江苏 徐州 221002
通讯作者 茂衡 祖 Email: zumaoheng@163.com
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2015.06.018
基金:
江苏省高等学校自然科学基金资助项目 12KJD310007

摘要

目的:应用计算机仿真的方法研究Budd-Chiari 综合征(BCS)下腔静脉隔膜生长过程中血管的血流动力学变化。方法:基于MRA 图像建立下腔静脉隔膜阻塞型BCS 血管模型,利用Ansys Fluent 软件进行血流参数仿真。结果:成功建立下腔静脉隔膜阻塞型BCS 血管模型。模型实验结果显示,在隔膜生长过程中,在下腔静脉及3 支主干肝静脉汇合处与隔膜之间有一低速区,该区域面积随隔膜的增长而逐渐变大;随着隔膜的发展,下腔静脉及肝右静脉低剪切力的区域不断扩大,而切应力变大。结论:下腔静脉隔膜的发生发展是一个缓慢变化的过程,可能与下腔静脉壁面剪切力的变化密切相关。


Numerical simulation of hemodynamics in Budd-Chiari syndrome caused by membrane obstruction of the inferior vena cava

Abstract

Objective: To investigate the vascular hemodynamic changes during the formation of obstructive membrane of the inferior vena cava (IVC) in Budd-Chiari syndrome (BCS) using computer simulation methods. Methods: The vascular model of BCS caused by membranous obstruction of the IVC was established based on MRA slice images, and then numerical simulation of hemodynamic parameter changes was demonstrated by using Ansys Fluent software. Results: The vascular model of BCS with membranous obstruction of the IVC was established successfully. The results of numerical simulation experiments demonstrated that during the formation of the obstructive membrane, there was a low flow speed region between the membrane and the region of confluence of the IVC and the three main hepatic veins, which increasingly enlarged with the extension of the membrane; with the development of the membrane, the low shear stress field located close to the IVC and the right hepatic vein was continuously amplified, and moreover, the shear stress gradually increased. Conclusion: The formation and development of the obstructive membrane of the IVC is a process of slow change, which may be closely related to alterations in shear stress of the wall of IVC.


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引用

引用本文: 银苹 庄, 权 王, 琳 侯, 彬 张, 思远 周, 阿明 王, 茂衡 祖. 下腔静脉隔膜阻塞型Budd-Chiari 综合征血流数值模拟[J]. 中国普通外科杂志, 2015, 24(6): 857-860.
Cite this article as: ZHUANG Yinping, WANG Quan, HOU Lin, ZHANG Bin, ZHOU Siyuan, WANG Aming, ZU Maoheng . Numerical simulation of hemodynamics in Budd-Chiari syndrome caused by membrane obstruction of the inferior vena cava[J]. Chin J Gen Surg, 2015, 24(6): 857-860.