临床研究(Clinical Research)

甲状腺功能异常与血脂水平的相关性研究

Published at: 2015年第24卷第6期

黄敏 1 , 肖创清 1
1 中国人民解放军第一六三中心医院 检验科,湖南 长沙 410003
通讯作者 创清 肖 Email: xcq163jyk@sina.com
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2015.06.019
基金:

摘要

目的:探讨甲状腺功能异常与血脂水平的关系。方法:选择2013 年4 月—2015 年3 月收治的甲状腺功能异常患者200 例为研究对象,其中甲状腺功能亢进症与甲状腺功能减退症患者各100 例,以同期健康体检者80 例为对照,检测受试者甲状腺激素与血脂水平,并分析两者相关性。结果:单因素分析显示,3 组间各甲状腺激素与血脂指标差异均有统计学意义(均P<0.05);相关系分析显示,甲状腺功能异常患者促甲状腺激素(TSH)与总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B100(ApoB100)呈正相关(r=0.695、0.714、0.632);游离三碘甲状腺原氨酸(FT3)与TC、LDL-C、ApoB100 呈负相关(r=-0.769、-0.705、-0.689);游离甲状腺素(FT4)与TC、LDL-C、ApoB100 呈负相关(r=-0.728、-0.676、-0.625)(均P<0.05)。结论:甲状腺功能异可导致血脂代谢的紊乱,临床上应予注意。


Correlation between thyroid disorders and blood lipid level

Abstract

Objective: To investigate the relationship between thyroid dysfunction and blood lipid level. Methods: Two hundred patients with thyroid function problems admitted during April 2013 to March 2015 were enrolled for the study, including 100 cases each with hyperthyroidism or hypothyroidism, and 80 participants undergoing health maintenance examination during the same period served as control. The levels of thyroid hormones and blood lipids in all subjects were measured, and the correlation between their levels was analyzed. Results: By univariate analysis, significant difference was found in all the studied thyroid hormones and blood lipids among the three populations (all P<0.05). Correlation analysis in patients with abnormal thyroid function showed that the level of thyroid stimulating hormone (TSH) had a positive correlation with the levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), and apolipoprotein B100 (ApoB10) (r=0.695, 0.714, and 0.632); the level of free triiodothyronine (FT3) had a negative correlation with the levels of TC, LDL-C and ApoB100 (r=–0.769, –0.705 and –0.689); the level of free thyroxine (FT4) had a negative correlation with the levels of TC, LDL-C and ApoB100 (r=–0.728, –0.676 and –0.625) (all P<0.05). Conclusion: Thyroid dysfunction may cause blood lipid metabolic abnormity, which deserves attention in clinical practice.


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引用

引用本文: 敏 黄, 创清 肖. 甲状腺功能异常与血脂水平的相关性研究[J]. 中国普通外科杂志, 2015, 24(6): 861-864.
Cite this article as: HUANG Min, XIAO Chuangqing . Correlation between thyroid disorders and blood lipid level[J]. Chin J Gen Surg, 2015, 24(6): 861-864.