文献综述(Review)

ciRS-7/miR-7 轴调控肿瘤生长转移的研究进展

Published at: 2015年第24卷第7期

刘彦 1 , 周超 2 , 杨永学 1
1 四川省成都市第五人民医院 消化内科,四川 成都 611130
2 四川省成都市第六人民医院 普通外科,四川 成都 610051
通讯作者 永学 杨 Email: zhengxiaobo1023@163.com
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2015.07.020
基金:

摘要

抑癌因子miRNA-7(miR-7)在肿瘤组织发生中表达下降,但机制未明。最近发现环状RNA-7(ciRS-7)具有miR-7 海绵样吸附作用,从而抑制miR-7 的功能,该发现为探索miR-7 在肿瘤中表达降低的原因开辟了新的途径。目前认为ciRS-7/miR-7 轴不仅具有重要的生物学作用,同时参与机体多种疾病的发生发展。笔者就ciRS-7/miR-7 轴调控肿瘤生长转移的研究进展进行综述。


Regulative role of ciRS-7/miR-7 axis in tumor growth and metastasis: recent advances

Abstract

Tumor suppressor miRNA-7 (miR-7) is found down-regulated in cancer tissues, but the underlying mechanism remains elusive. Recent studies demonstrated that circular RNA-7 (ciRS-7) acts as a sponge for miR-7 and thus can inhibit the miRNA-7 activity. This finding provided a new perspective for revealing the mechanisms of decreased expression of miR-7 in tumors. It is now believed that the ciRS-7/miR-7 axis not only has important biological functions, but participates in the occurrence and development of a range of diseases. Here, the authors present the research progress in ciRS-7/miR-7 axis regulating tumor growth and metastasis.


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引用

引用本文: 彦 刘, 超 周, 永学 杨. ciRS-7/miR-7 轴调控肿瘤生长转移的研究进展[J]. 中国普通外科杂志, 2015, 24(7): 1027-1031.
Cite this article as: LIU Yan, ZHOU Chao, Yang Yongxue . Regulative role of ciRS-7/miR-7 axis in tumor growth and metastasis: recent advances[J]. Chin J Gen Surg, 2015, 24(7): 1027-1031.