胆道肿瘤专题研究(Monographic Study of Biliary Tract Neoplasms)

胆囊癌发病相关危险因素分析

Published at: 2015年第24卷第2期

徐建庆 1,2 , 陈晨 1 , 宋虎伟 1 , 耿西林 3 , 赵亚玲 4 , 王林 1 , 耿智敏 1
1 西安交通大学医学院第一附属医院 肝胆外科,陕西 西安 710061
2 西安高新医院 普通外科,陕西 西安 710075
3 陕西省人民医院 肝胆外科,陕西 西安 710061
4 西安交通大学医学部公共卫生学院 统计系,陕西 西安 710061
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2015.02.007
基金:
陕西省科学技术厅科技攻关项目资助 2014K11-03-03-12
陕西省科学技术厅国际合作科技攻关资助项目 2414KW23-01

摘要

目的:探讨胆囊癌发病的相关危险因素,为有效预防和控制胆囊癌的发生提供理论依据。方法:回顾性分析2008年1月―2013年3月西安交通大学第一附属医院肝胆外科收治的802例胆囊癌患者资料,并以同期收治的815例非胆囊癌患者(排除与研究变量有明显相关的人群及病种)为对照,采用病例对照研究方法,分析胆囊癌发病相关危险因素分析。结果:经单因素分析选择自变量后,再行Logistic多因素分析,结果显示,年龄(50~70岁)、职业(农民)、体质量指数(≥27)、生育次数(≥3次)、绝经年龄(>50岁)、血型(A型)、胆囊结石及慢性胆囊炎病史是胆囊癌发生的独立危险因素(均P<0.05)。结论:以上因素可供临床结合具体病例参考,以利于胆囊癌的早期发现及早期治疗。


Analysis of relevant factors in pathogenesis of gallbladder cancer

Abstract

Objective: To determine the relevant factors in pathogenesis of gallbladder cancer, so as to provide a theoretical reference for preventing and controlling the development of this disease. Methods: The clinical records of 802 patients with gallbladder cancer (gallbladder cancer group) admitted to the Department of hepatobiliary surgery, the First Affiliated Hospital of Medical College of Xian Jiaotong University from February 2008 to March 2013 were reviewed, and 815 non-gallblader cancer patients (excluding the population and diseases that had obvious relevance to the studied varibles) admitted during the same period served as control. Using a case-control design, the relevant risk factors for gallbladder cancer were analyzed. Results: After independent variable assessment by univariate analysis, multivariate Logistic regression was conducted and the results demonstrated that age (50–70), occupation (farmer), body mass index (≥27), gestational number (≥3), age of menopause (>50), blood type (type A), history of cholecystolithiasis and chronic cholecystitis were the independent risk factors for the occurrence of gallbladder cancer (all P<0.05). Conclusion: The above factors may provide reference for the specific case in clinical practice, and facilitate early detection and therapy of gallbladder cancer.


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引用

引用本文: 建庆 徐, 晨 陈, 虎伟 宋, 西林 耿, 亚玲 赵, 林 王, 智敏 耿. 胆囊癌发病相关危险因素分析[J]. 中国普通外科杂志, 2015, 24(2): 190-194.
Cite this article as: XU Jianqing, CHEN Chen, SONG Huwei, GENG Xilin, ZHAO Yaling, WANG Lin, GENG Zhimin . Analysis of relevant factors in pathogenesis of gallbladder cancer[J]. Chin J Gen Surg, 2015, 24(2): 190-194.