目的：探讨术前血清CEA 与CA19-9 水平在结肠癌根治术后早期复发转移的预测价值。方法：收集2012 年1 月—2015 年1 月收治的129 例术后发生复发转移结肠癌患者的临床资料，分析术前静脉血清CEA 和CA19-9 水平与患者术后早期复发转移及其他临床病理学参数的关系。结果：129 例结肠癌患者中术后早期复发转移（术后12 个月内）82 例，晚期复发转移（超过12 个月）47 例；术前CEA 阳性者74 例中，早期复发转移56 例（75.8%），术前CA19-9 阳性者68 例中，早期复发转移51 例（75.0%）。统计分析显示，结肠癌术后早期复发转移与术前CEA 与CA19-9 阳性密切相关；术前CEA 和CA19-9 阳性患者与T 分期与TNM 分期升高及淋巴结转移及脉管浸润比例增加；术前CEA 与CA19-9 阳性患者术后早期复发转移率分别高于各自阴性患者，且两者均阳性患者早期复发转移率高于单一阳性或双阴性患者，差异均有统计学意义（均P<0.05）。结论：术前血清CEA 与CA19-9 水平检测在结肠癌术后早期复发转移和预后判断中具有重要价值，术前两者均阳性患者预后差。
Predictive significance of preoperative serum CEA and CA19-9 determination in early recurrence/metastasis of colon cancer after operation
Objective: To investigate the value of serum CEA and CA19-9 in predicting early recurrence/metastasis of colon cancer after radical surgery. Methods: The clinical data of 129 patients with postoperative recurrence and metastasis of colon cancer and treated from January 2012 to January 2015 were collected. The relations of preoperative CEA and CA19-9 levels with early postoperative recurrence/metastasis and other clinicopathologic variables were analyzed. Results: Of the 129 patients, early recurrence/metastasis (within 12 months after surgery) occurred in 82 cases and another 47 cases had late recurrence/metastasis (over 12 months after surgery); early recurrence/ metastasis occurred in 56 of the 74 patients with positive preoperative CEA and 51 of the 68 patients with positive preoperative CA19-9. Statistical analyses showed that there was a close relationship between early postoperative recurrence/metastasis of colon cancer and preoperative CEA or CA19-9 level; the ratios of cases with advanced T or TNM stage, lymph node metastasis or vascular invasion was increased in patients with positive preoperative CEA or CA19-9. The rate of early postoperative recurrence/metastasis in patients with positive preoperative CEA or CA19-9 was significantly higher than that in corresponding negative ones, and in patients with both positive CEA and CA19-9 was significantly higher than that in either single positive or double negative ones, and all differences had statistical significance (all P<0.05). Conclusion: Preoperative determination of serum CEA and CA19-9 levels has important significance in predicting early postoperative recurrence/metastasis of colon cancer, and patients with both positive CEA and CA19-9 may face a poor prognosis.