文献综述(Review)

胰腺癌干细胞研究进展

Published at: 2015年第24卷第9期

朱建伟 1 , 熊力 1 , 马望 2 , 张亚娜 2 , 文宇 1 , 苗雄鹰 1
1 中南大学湘雅二医院 普通外科,湖南 长沙 410011
2 郑州大学第一附属医院 肿瘤科,河南 郑州 450000
通讯作者 宇 文 Email: wenyu2861@163.com
DOI: 10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2015.09.019
基金:
国家自然科学基金资助项目 (81372628)

摘要

胰腺癌干细胞(PCSC)在胰腺癌的发生、发展过程中起着重要作用,且与胰腺癌的耐药、转移机制关系密切。PCSC的表面标志物、分离、鉴定、信号通路、微环境、耐药、转移和靶向治疗等方面的研究,将为临床胰腺癌的治疗提供新的方向。


Research progress of pancreatic cancer stem cells

Abstract

Pancreatic cancer stem cells (PCSCs) play an important role in the occurrence and development of pancreatic cancer, and are also closely related to the mechanisms for chemotherapy resistance and metastasis of pancreatic cancer. Investigations of PCSCs with regard to their surface markers, isolation, identification, signal pathways, microenvironment, drug resistance, metastasis and targeted therapy may provide a new prospect for the clinical treatment of pancreatic cancer.


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引用

引用本文: 建伟 朱, 力 熊, 望 马, 亚娜 张, 宇 文, 雄鹰 苗. 胰腺癌干细胞研究进展[J]. 中国普通外科杂志, 2015, 24(9): 1304-1309.
Cite this article as: ZHU Jianwei, XIONG Li, MA Wang, ZHANG Yana, WEN Yu, MIAO Xiongying . Research progress of pancreatic cancer stem cells[J]. Chin J Gen Surg, 2015, 24(9): 1304-1309.