胃癌神经侵犯的相关临床病理因素：单中心509例分析
| 作者: |
1殷凯,
1瞿建国,
1陈吉祥,
2赵小辉,
1党胜春
1 江苏大学附属医院普通外科，江苏 镇江 212001 2 江苏大学附属医院病理科，江苏 镇江 212001 |
| 通讯: |
党胜春
Email: dscgu@163.com |
| DOI: | 10.3978/.2018.04.002 |
| 基金: | 江苏省六大人才高峰资助项目（2016-WSN-007）；江苏省“333工程”科研基金资助项目（BRA2017560）；江苏省镇江市重点研发计划-社会发展基金资助项目（SH2017023；SH2015066）。 |
摘要
目的：分析胃癌患者神经侵犯（PNI）的相关临床病理因素。
方法：收集江苏大学附属医院2014年6月—2017年6月509例胃癌患者的临床和病理资料，分析PNI与患者临床病理因素的关系。
结果：509例胃癌患者中，神经侵犯阳性患者250例，阴性患者259例。单因素分析显示，胃癌PNI与肿瘤浸润深度、组织分化程度、淋巴结转移和TNM分期有关（均P<0.001），而与患者年龄、性别无关（均P>0.05）；趋势χ2检验显示胃癌PNI与肿瘤浸润深度相关性最大（r=0.623，P<0.001）；二分类Logistic回归分析表明肿瘤浸润深度为胃癌神经侵犯的独立危险因素（OR=6.285，95% CI= 4.009~9.854，P<0.001）。
结论：胃癌患者PNI与肿瘤浸润深度、组织分化程度、淋巴结转移数目和TNM分期有关，其中肿瘤浸润深度可能是最重要的因素。
关键词：
方法：收集江苏大学附属医院2014年6月—2017年6月509例胃癌患者的临床和病理资料，分析PNI与患者临床病理因素的关系。
结果：509例胃癌患者中，神经侵犯阳性患者250例，阴性患者259例。单因素分析显示，胃癌PNI与肿瘤浸润深度、组织分化程度、淋巴结转移和TNM分期有关（均P<0.001），而与患者年龄、性别无关（均P>0.05）；趋势χ2检验显示胃癌PNI与肿瘤浸润深度相关性最大（r=0.623，P<0.001）；二分类Logistic回归分析表明肿瘤浸润深度为胃癌神经侵犯的独立危险因素（OR=6.285，95% CI= 4.009~9.854，P<0.001）。
结论：胃癌患者PNI与肿瘤浸润深度、组织分化程度、淋巴结转移数目和TNM分期有关，其中肿瘤浸润深度可能是最重要的因素。
Clinicopathologic factors related to perineural invasion of gastric cancer: analysis of 509 cases in a single center
CorrespondingAuthor:DANG Shengchun Email: dscgu@163.com
Abstract
Objective: To investigate the relevant clinicopathologic factors for perineual invasion (PNI) in gastric cancer patients.
Methods: The clinical and pathological data of 509 gastric cancer patients treated in the Affiliated Hospital of Jiangsu University from June 2014 to June 2017 were collected. The relations of PNI with clinicopathologic factors were analyzed.
Results: Of the 509 gastric cancer patients, 250 cases were PNI positive and 259 cases were PNI negative. Univariate analysis showed that PNI in gastric cancer was significantly associated with the tumor infiltration depth, degree of tissue differentiation, lymph node metastasis and TNM stage (all P<0.001), but irrelevant to age and gender (both P>0.05). The χ2 tests for trend reported that PNI had a maximum correlation with tumor infiltration depth (r=0.623, P<0.001). The binomial Logistic regression analysis showed that tumor infiltration depth was an independent risk factor for PNI (OR=6.285, 95% CI=4.009–9.854, P<0.001).
Conclusion: PNI in gastric cancer patients is associated with the degree of tissue differentiation, tumor infiltration depth, lymph node metastasis and TNM stage, in which the tumor infiltration depth is probably the most important factor.
Keywords：
Methods: The clinical and pathological data of 509 gastric cancer patients treated in the Affiliated Hospital of Jiangsu University from June 2014 to June 2017 were collected. The relations of PNI with clinicopathologic factors were analyzed.
Results: Of the 509 gastric cancer patients, 250 cases were PNI positive and 259 cases were PNI negative. Univariate analysis showed that PNI in gastric cancer was significantly associated with the tumor infiltration depth, degree of tissue differentiation, lymph node metastasis and TNM stage (all P<0.001), but irrelevant to age and gender (both P>0.05). The χ2 tests for trend reported that PNI had a maximum correlation with tumor infiltration depth (r=0.623, P<0.001). The binomial Logistic regression analysis showed that tumor infiltration depth was an independent risk factor for PNI (OR=6.285, 95% CI=4.009–9.854, P<0.001).
Conclusion: PNI in gastric cancer patients is associated with the degree of tissue differentiation, tumor infiltration depth, lymph node metastasis and TNM stage, in which the tumor infiltration depth is probably the most important factor.