文章摘要

药物涂层球囊治疗下肢动脉硬化闭塞病变的现状

作者: 1焦 玉浩, 1齐 立行
1 首都医科大学宣武医院 血管外科,北京 100053
通讯: 齐 立行 Email: 843876674@qq.com
DOI: 10.3978/.2018.06.016
基金: 国家重点研发计划资助项目(2017YFC1104100);北京市医院管理局临床技术创新基金资助项目 [(扬帆计划) XMLX201610]; 北京市医院管理局“登峰”人才培养计划资助项目(DFL20150801);宣武医院“英才培养计划”。

摘要

下肢动脉粥样硬化闭塞性疾病腔内治疗的模式在最近十年取得了很大的进展,从最初的单纯球囊扩张到支架成形,再发展到以药物涂层球囊、斑块切除和激光销蚀为代表的无移植物“leave nothing behind”手术。为应对单纯球囊扩张成形术和支架置入术后高再狭窄率的顽疾,近 5 年来在全球范围,尤其是国内自 2016 年 6 月开始了药物涂层球囊治疗下肢动脉硬化闭塞症的尝试,取得了理想的治疗效果。笔者概括介绍药物涂层球囊的原理和技术,并回顾现有的随机对照试验。
关键词: 闭塞性动脉硬化;下肢;药物涂层球囊;综述文献

Drug-coated balloon in treatment of lower limb atherosclerosis obliterans: current status

Authors: 1JIAO Yuhao, 1QI Lixing
1 Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

CorrespondingAuthor:QI Lixing Email: 843876674@qq.com

Abstract

The mode of endovascular treatment for atherosclerosis obliterans of the lower limbs has evolved significantly over the last decade, from the initial percutaneous transluminal angioplasty (PTA) to stenting, and then to the implant-free surgery following the "leave nothing behind" concept that is represented by drug-coated balloon, plaque excision and laser erosion. In an att empt to overcome the stubborn problem of high restenosis rates aft er PTA and stenting, the att empts of using drug-coated balloon in treatment of atherosclerosis obliterans of the lower limbs have been started worldwide in the past fi ve years and especially in China since June 2016, and favorable therapeutic results have been obtained. Here, the authors provide an overview of the rationale and the technology of DCB and review currently available data from randomized controlled trials.
Keywords: Arteriosclerosis Obliterans; Lower Extremity; Drug-Coated Balloon; Review