Objective: To evaluate the safety and effectiveness of delayed-immediate breast reconstruction after radical mastectomy. Methods: The clinical data of 100 randomly selected patients undergoing delayed-immediate breast reconstruction after modified radical mastectomy from October 2010 to October 2013 were retrospectively analyzed. In the reconstruction methods among the 100 patients, latissimus dorsi musculocutaneous flap plus expander implant (LD+expander) was performed in 39 cases, pectoralis major muscle combined with acellular dermal matrix plus expander implant (ADM+expander) was performed in 6 cases, and direct expander implant was performed in 55 cases. Results: In the entire group, both subjective and objective satisfactory rates were 92.0%. The excellent and good rate of postoperative subjective and objective satisfaction in patients undergoing LD+expander implant was 84.6% and 89.7%, was 60% and 65.5% in patients undergoing direct expander implant, and was both 100.0% in patients undergoing ADM+expander implant, respectively. Statistical analysis showed (those undergoing ADM+expander implant were not included due to the small number of cases) that both degrees in subjective and objective satisfaction in patients undergoing LD+expander implant were higher than those in patients receiving direct expander implant (both P<0.05). Conclusion: Using LD+expander implant for delayed-immediate breast reconstruction after radical mastectomy offers a better patients’ satisfaction, with less cost than that of ADM+expander implant, so it is recommended as first option.