Objective: To investigate the influential factors for hypercoagulable state formation in patients after laparoscopic cholecystectomy. Methods: One hundred and eight patients undergoing laparoscopic cholecystectomy from January 2012 to December 2015 were prospectively selected as study subjects. The differences in the relevant clinical variables were compared between patients with and without hypercoagulable state formation, and the factors for postoperative hypercoagulable state formation were analyzed. Results: Of the 108 patients undergoing laparoscopic cholecystectomy, 32 cases (29.63%) were found having a hypercoagulable state. In patients with hypercoagulable state compared with those without hypercoagulable state, the proportion of cases with hyperlipidemia history and preoperative levels of systolic blood pressure, fibrinogen (Fbg), D-dimer (D-D), platelet count (PLT), prothrombin fragments (F1+F2), transferrin (Trf), alpha acid glycoprotein (Orso), C-reactive protein (CRP), interleukin 6 (IL-6), and low density lipoprotein cholesterol (LDL-C) were significantly increased, while the high density lipoprotein cholesterol (HDL-C) level was significantly decreased (all P<0.05). Univariate and multivariate Logistic regression analyses showed that hyperlipidemia history, Fbg≥3.95g/L, D-D≥100.00 µg/L, PLT≥228.00×109/L, F1+F2≥0.16 nmol/L, Trf≥2.15 g/L, Orso≥0.85 g/L, CRP≥1.50 mg/L, IL-6≥1.50 pg/mL, LDL-C≥2.85 mg/dL were independent risk factors for hypercoagulable state formation after laparoscopic cholecystectomy (all P<0.05). Conclusion: For patients undergoing laparoscopic cholecystectomy, attention should be paid to the occurrence of hypercoagulable state formation in those with above risk factors.