Objective: To investigate the feasibility and efficacy of laparoscopic first stage and open second stage ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) in treatment of huge hepatocellular carcinoma (HCC). Methods: The clinical data of 12 patients with huge HCC with concomitant liver cirrhosis undergoing laparoscopic first stage and open second stage ALPPS from April 2014 to April 2016 were retrospectively analyzed. Results: Before treatment, all patients were classified as Child B liver function, the average ICGR15 was (23.4±1.5)%, and the estimated future liver remnant (FLR) was (308±64) mL with a ratio of (27±3.8)% to the total estimated liver volume. In the first-stage operation, except one case of open conversion, laparoscopic procedure was successfully performed in all remaining cases; after the first-stage operation, the liver function transferred to Child A in all patients, the average ICGR15 was (8.6±4.2)%, and FLR was (684±129) mL with a ratio of (56±7.7)% to the total estimated liver volume. The average time interval between the first- and second-stage operations was 10.5 (7–16) d. in the open second-stage operation, 7 patients underwent extended right hemihepatectomy and 5 patients underwent right hepatic trisegmentectomy, with an average intraoperative blood loss of 650 (200–1 200) mL and blood transfusion of 3.5 (1.5–6) U respectively. No severe postoperative complications occurred, and the ascites and transient bile leakage were resolved by conservative treatments. Postoperative follow-up was conducted for 6 to 30 months, during which time, 3 patients died and the remaining patients were alive. Conclusion: Laparoscopic first stage and open second stage ALPPS is a safe and effective treatment method for huge HCC.