文章摘要

胰腺导管腺癌肿瘤微环境的研究进展

作者: 1,2邢荣春, 3,4秦周萍
1 三峡大学第一临床医学院 急诊与创伤外科，湖北 宜昌443003
2 湖北省宜昌市中心人民医院 急诊与创伤外科，湖北 宜昌443003
3 三峡大学人民医院 心胸外科，湖北 宜昌443002
4 湖北省宜昌市第一人民医院 心胸外科， 湖北 宜昌443002
通讯: 秦周萍 Email: qinzhouping2015@163.com
DOI: 10.3978/.10.3978/j.issn.1005-6947.10.3978/j.issn.1005-6947.2017.09.019

摘要

胰腺导管腺癌（PDAC）是一种恶性程度极高、早期难以诊断、预后极差的恶性肿瘤。近年来的研究发现肿瘤微环境及免疫调节与PDAC的发生密切相关，生物学微环境的研究可能为这种致死性癌症的治疗提供新的策略。笔者就PDAC肿瘤微环境研究的最新进展进行综述。
关键词： 胰腺肿瘤 肿瘤微环境 免疫调节 综述文献

Research progress of tumor microenvironment in pancreatic ductal adenocarcinoma

Authors: 1,2XING Rongchun, 3,4QIN Zhouping
1 Department of Emergency and Traumatic Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei 443003, China
2 Department of Emergency and Traumatic Surgery, Yichang Central People’s Hospital, Yichang, Hubei 443003, China
3 Department of Cardiothoracic Surgery, People’s Hospital of China Three Gorges University, Yichang, Hubei 443002, China
4 Department of Cardiothoracic Surgery, Yichang First People’s Hospital, Yichang, Hubei 443002, China

CorrespondingAuthor:QIN Zhouping Email: qinzhouping2015@163.com

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with aggressive biological behavior, difficult diagnosis at an early stage and dismal outcome. Recent investigations showed that the tumor microenvironment and immunomodulation are closely related to the occurrence of PDAC, and researches upon the biological environment may provide new strategies for the treatment of this lethal condition. The authors address the research progress in the field of PDAC microenvironment.
Keywords： Pancreatic Neoplasms tumor microenvironment Immunomodulation Review