胰腺神经内分泌肿瘤8例临床分析
| 作者: |
1张宇,
2孟兴凯,
2张俊晶
1 内蒙古医科大学 研究生学院，内蒙古 呼和浩特 010030 2 内蒙古医科大学附属医院 肝胆外科，内蒙古 呼和浩特 010050 |
| 通讯: |
张俊晶
Email: zjj7811@gmail.com |
| DOI: | 10.3978/.2018.03.007 |
| 基金: | 内蒙古自治区草原英才培训专项基金资助项目（CYYC2012040）。 |
摘要
目的：探讨胰腺神经内分泌肿瘤（pNET）的诊疗方法及预后。
方法：回顾性分析2008年1月—2017年1月间内蒙古医科大学附属医院收治的8例pNET患者的临床资料。
结果：8例pNET患者，男2例，女6例；年龄36~72岁，平均年龄53岁；均行影像学检查明确病灶；5例无功能性肿瘤主要表现为腹痛腹胀、腹部肿块、食欲不振、消瘦，3例功能性肿瘤以低血糖反应或高血糖为主要表现；均行手术治疗，其中1例行肿瘤局部切除术，2例行胰体尾联合切除术，4例行胰十二指肠切除术，1例行胰体尾+脾切除术+胰腺空肠吻合术。8例随访30~66个月，7例存活，1例死亡。
结论：结合实验室和影像学检查，有助于该病的诊断；确定合理可行的综合治疗方法，可提高治愈率、改善患者生活质量和预后。
关键词：
胰腺肿瘤/诊断；胰腺肿瘤/治疗；神经内分泌瘤；预后
方法：回顾性分析2008年1月—2017年1月间内蒙古医科大学附属医院收治的8例pNET患者的临床资料。
结果：8例pNET患者，男2例，女6例；年龄36~72岁，平均年龄53岁；均行影像学检查明确病灶；5例无功能性肿瘤主要表现为腹痛腹胀、腹部肿块、食欲不振、消瘦，3例功能性肿瘤以低血糖反应或高血糖为主要表现；均行手术治疗，其中1例行肿瘤局部切除术，2例行胰体尾联合切除术，4例行胰十二指肠切除术，1例行胰体尾+脾切除术+胰腺空肠吻合术。8例随访30~66个月，7例存活，1例死亡。
结论：结合实验室和影像学检查，有助于该病的诊断；确定合理可行的综合治疗方法，可提高治愈率、改善患者生活质量和预后。
Pancreatic neuroendocrine tumors: a clinical analysis of 8 cases
CorrespondingAuthor:ZHANG Junjing Email: zjj7811@gmail.com
Abstract
Objective: To investigate the diagnosis and treatment methods as well as prognosis of pancreatic neuroendocrine tumors (pNETs).
Methods: The clinical data of 8 patients with pNETs treated from January 2008 to January 2017 in the Affiliated Hospital of Inner Mongolia Medical University were retrospectively analyzed.
Results: Of the 8 patients, two cases were male and 6 cases were female, and the age ranged from 36 to 72 years with an average age of 53 years; the lesions in all cases were ascertained by imaging examinations; 5 cases were non-functioning tumors with main symptoms of abdominal pain or bloating, abdominal mass, inappetence and emaciation, and 3 caseswere functioning tumors with main symptoms of hypoglycemic reaction or hyperglycemia; one case underwent tumor enucleation, two cases underwent distal pancreatectomy, 4 cases underwent pancreaticoduodenectomy and one case underwent distal pancreatectomy plus splenectomy with pancreaticojejunostomy. The 8 patients were followed up for 30 to 66 months, during which period, 7 cases were still alive, and one case died.
Conclusion: Combination of laboratory tests and imaging examinations will be helpful for the diagnosis of this condition, and rational and feasible combined treatment can increase the cure rate, and improve the quality of life and prognosis of the patients.
Keywords：
Pancreatic Neoplasms/diag; Pancreatic Neoplasms/ther; Neuroendocrine Tumors; Prognosis
Methods: The clinical data of 8 patients with pNETs treated from January 2008 to January 2017 in the Affiliated Hospital of Inner Mongolia Medical University were retrospectively analyzed.
Results: Of the 8 patients, two cases were male and 6 cases were female, and the age ranged from 36 to 72 years with an average age of 53 years; the lesions in all cases were ascertained by imaging examinations; 5 cases were non-functioning tumors with main symptoms of abdominal pain or bloating, abdominal mass, inappetence and emaciation, and 3 caseswere functioning tumors with main symptoms of hypoglycemic reaction or hyperglycemia; one case underwent tumor enucleation, two cases underwent distal pancreatectomy, 4 cases underwent pancreaticoduodenectomy and one case underwent distal pancreatectomy plus splenectomy with pancreaticojejunostomy. The 8 patients were followed up for 30 to 66 months, during which period, 7 cases were still alive, and one case died.
Conclusion: Combination of laboratory tests and imaging examinations will be helpful for the diagnosis of this condition, and rational and feasible combined treatment can increase the cure rate, and improve the quality of life and prognosis of the patients.