胰腺神经内分泌肿瘤5例报告并文献复习
| 作者: |
1赵臣,
1贾国洪,
1贾志芳
1 中国人民解放军第二五一医院 普通外科，河北 张家口 075000 |
| 通讯: |
贾国洪
Email: jgh@163.com |
| DOI: | 10.3978/.2018.03.008 |
摘要
目的：分析胰腺神经内分泌肿瘤（PNENs）的临床特征与诊治方法。
方法：回顾性分析2013年6月—2016年6月收治的5例PNENs患者临床资料。
结果：PNENs 5例中，男2例，女性3例；均行B超及CT检查，1例患者行PET-CT；年龄48~75岁；临床表现各异，且无特异性；实验室检查无特异性指标；4例患者行手术治疗，1例仅行穿刺活检。病理（根据2010年WHO分期）结果为G1期2例，G2期1例，G3期2例。5例均随访，1例术后12个月因肝转移死亡，其余均恢复良好。
结论：PNENs大多缺乏特征性临床表现，术前诊断困难，主要依靠术后病理组织学检查，治疗方法主要是手术为主的综合治疗，预后较好。
关键词：
胰腺肿瘤/诊断；胰腺肿瘤/治疗；癌，神经内分泌
方法：回顾性分析2013年6月—2016年6月收治的5例PNENs患者临床资料。
结果：PNENs 5例中，男2例，女性3例；均行B超及CT检查，1例患者行PET-CT；年龄48~75岁；临床表现各异，且无特异性；实验室检查无特异性指标；4例患者行手术治疗，1例仅行穿刺活检。病理（根据2010年WHO分期）结果为G1期2例，G2期1例，G3期2例。5例均随访，1例术后12个月因肝转移死亡，其余均恢复良好。
结论：PNENs大多缺乏特征性临床表现，术前诊断困难，主要依靠术后病理组织学检查，治疗方法主要是手术为主的综合治疗，预后较好。
Pancreatic neuroendocrine neoplasms: a report of 5 cases and literature review
CorrespondingAuthor:JIA Guohong Email: jgh@163.com
Abstract
Objective: To analyze the clinical features as well as the diagnosis and treatment methods of pancreatic neuroendocrine neoplasms (PNENs).
Methods: The clinical data of 5 patients with PNENs treated from June 2013 to June 2016 were retrospectively analyzed.
Results: Of the 5 patients, 2 cases were male and 3 were female and age ranged from 48 to 57 years. All of the cases underwent ultrasound and CT examination, and one case had PET-CT examination. The clinical manifestations were varied with no specificity and the results of laboratory tests showed no significant findings. Four cases underwent surgical treatment, and one case underwent puncture biopsy only. The pathological results (based on the 2010 WHO classification) showed stage G1 in 2 cases, stage G2 in 1 case, and stage G3 in 2 cases, respectively. All of the 5 patients were followed up; one case died at 12 months postoperatively due to liver metastasis and the remaining cases recovered well.
Conclusion: Most PNENs lack characteristic clinical manifestations, so preoperative diagnosis is difficult and it mainly depends on postoperative pathology. Surgery-based multimodality therapy is the main treatment method for PNENs, and offers better prognosis.
Keywords：
Pancreatic Neoplasms/diag; Pancreatic Neoplasms/ther; Carcinoma
Neuroendocrine
Methods: The clinical data of 5 patients with PNENs treated from June 2013 to June 2016 were retrospectively analyzed.
Results: Of the 5 patients, 2 cases were male and 3 were female and age ranged from 48 to 57 years. All of the cases underwent ultrasound and CT examination, and one case had PET-CT examination. The clinical manifestations were varied with no specificity and the results of laboratory tests showed no significant findings. Four cases underwent surgical treatment, and one case underwent puncture biopsy only. The pathological results (based on the 2010 WHO classification) showed stage G1 in 2 cases, stage G2 in 1 case, and stage G3 in 2 cases, respectively. All of the 5 patients were followed up; one case died at 12 months postoperatively due to liver metastasis and the remaining cases recovered well.
Conclusion: Most PNENs lack characteristic clinical manifestations, so preoperative diagnosis is difficult and it mainly depends on postoperative pathology. Surgery-based multimodality therapy is the main treatment method for PNENs, and offers better prognosis.