文章摘要

胰腺癌干细胞研究进展

作者: 1朱建伟, 1熊力, 2马望, 2张亚娜, 1文宇, 1苗雄鹰
1 中南大学湘雅二医院 普通外科，湖南 长沙 410011
2 郑州大学第一附属医院 肿瘤科，河南 郑州 450000
通讯: 文宇 Email: wenyu2861@163.com
苗雄鹰 Email: 4896142@qq.com
DOI: 10.3978/.10.3978/j.issn.1005-6947.2015.09.019
基金: 国家自然科学基金资助项目, （81372628）

摘要

胰腺癌干细胞（PCSC）在胰腺癌的发生、发展过程中起着重要作用，且与胰腺癌的耐药、转移机制关系密切。PCSC的表面标志物、分离、鉴定、信号通路、微环境、耐药、转移和靶向治疗等方面的研究，将为临床胰腺癌的治疗提供新的方向。
关键词： 胰腺肿瘤；肿瘤干细胞；综述文献

Research progress of pancreatic cancer stem cells

Authors: 1ZHU Jianwei, 1XIONG Li, 2MA Wang, 2ZHANG Yana, 1WEN Yu, 1MIAO Xiongying
1 Department of General Surgery, the Second Xiangya Hospital, Central South University, Changsha 410011, China
2 Department of Oncology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450000, China

CorrespondingAuthor:WEN Yu Email: wenyu2861@163.com

Abstract

Pancreatic cancer stem cells (PCSCs) play an important role in the occurrence and development of pancreatic cancer, and are also closely related to the mechanisms for chemotherapy resistance and metastasis of pancreatic cancer. Investigations of PCSCs with regard to their surface markers, isolation, identification, signal pathways, microenvironment, drug resistance, metastasis and targeted therapy may provide a new prospect for the clinical treatment of pancreatic cancer.
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