Objective: To investigate the therapeutic efficacy of hybrid procedures for multisegmental lower extremity arteriosclerosis obliterans. Methods: The clinical data of 30 patients (30 affected limbs) with complicated lower extremity arteriosclerosis obliterans undergoing hybrid revascularization procedures from March 2014 to September 2014 were analyzed. Of the 30 patients, the lesion sites involved the aortoiloac, femoropopliteal, profunda femoris and infrapopliteal arteries; all cases underwent endovascular repair, of which, 20 cases were subjected to endarterectomy, 10 cases received arterial embolectomy, and 8 cases had profundaplasty. Results: The hybrid procedures were successfully performed in all the 30 patients, and technical success rate was 100%. The incidence of perioperative complications was 30% (9/30), the clinical success rate was 96.67% (29/30), and the postoperative average ankle-brachial index increased by an average of 0.37±0.19 compared with the preoperative value. The 6- and 12-month primary patency rate was 90% and 73%, and the 12-month limb salvage rate was 97.67%, respectively. Conclusion: The hybrid procedures offer excellent short-term patency and limb salvage rate for complicated arteriosclerosis obliterans of the lower extremities.