文章摘要

缺氧诱导因子2 与肝癌的研究进展

作者: 1潘婷婷, 2许戈良
1 天津医科大学研究生院，天津 300070
2 安徽医科大学附属省立医院肝脏外科/ 肝胆胰外科安徽省重点实验室，安徽 合肥 230001
通讯: 许戈良 Email: xugeliang2007@163.com
DOI: 10.3978/.10.3978/j.issn.1005-6947.2015.01.019
基金: 安徽省科学技术厅2011 年度科技计划资助项目, 11010402163

摘要

缺氧诱导因子2（HIF-2）是bHLH-PAS 超家族成员之一，能够应答细胞内氧气浓度的降低而对多种基 因的表达进行调控，且与肿瘤的发生、发展关系密切。肝细胞癌（肝癌）是我国最常见的恶性肿瘤之一， 治疗效果有限，病死率高，研究HIF-2 在肝癌中的作用可有助于改进治疗手段，改善患者预后。
关键词： 癌，肝细胞 缺氧诱导因子 综述文献

Role of hypoxia inducible factor 2 in hepatocellular carcinoma: recent advances

Authors: 1PAN Tingting, 2XU Geliang
1 Graduate School, Tianjin Medical University, Tianjin, 300070, China
2 Department of Hepatic Surgery, Anhui Provincial Hospital/Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Anhui Medical University, Hefei 230001, China

CorrespondingAuthor:XU Geliang Email: xugeliang2007@163.com

Abstract

Hypoxia inducible factor 2 (HIF-2) is a member of the basic helix-loop-helix/Per Arnt-Sim (bHLH-PAS) family, which can regulate the expressions of a variety of genes in response to intracellular hypoxia, and also closely related to tumor occurrence and development. Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in China, with limited therapeutic options and high mortality. So, investigation of the role of HIF-2 in HCC may provide insights into improving treatment access and outcomes of the patients.
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