胆管癌干细胞研究进展
| 作者: |
1邓小峰,
1王晓博,
1熊力,
1刘志鹏,
1苗雄鹰,
1文宇,
1杨乐平
1 中南大学湘雅二医院 普通外科，湖南 长沙410011 |
| 通讯: |
文宇
Email: wenyu2861@163.com 杨乐平 Email: yang_leping@sina.com |
| DOI: | 10.3978/.10.3978/j.issn.1005-6947.2015.02.021 |
| 基金: | 国家自然科学基金资助项目, 81372628 |
摘要
肿瘤干细胞是肿瘤组织中具有干细胞特性的细胞群体，具有自我更新和分化为多种恶性肿瘤细胞能力，拥有特征性的分子标记物与信号通路。笔者就用以鉴定胆管癌干细胞的各类标志物及信号通路进行阐述，并结合胆管癌干细胞的靶向治疗方面进行讨论。
关键词：
胆管肿瘤
肿瘤干细胞
分子标志物
综述文献
Research advances in cholangiocarcinoma stem cells
CorrespondingAuthor:WEN Yu Email: wenyu2861@163.com
Abstract
Tumor stem cells are a group of cells in tumor tissue with distinct molecular markers and specific signal pathways, which possess the properties of stem cells and the ability of self-renewal and differentiating to different tumor cells. In this paper, the authors address the molecular markers or signaling pathways for identification of cholangiocarcinoma stem cells, and also discuss the issues associated with the aspect of target therapy for cholangiocarcinoma.
Keywords：