Objective: To investigate the risk factors for postoperative gastroparesis syndrome (PGS) after colorectal cancer surgery and its diagnostic and treatment strategies. Methods: Clinical data of 806 patients undergoing radical resection of colorectal cancer from January 2013 to September 2014 were collected. The influential factors for occurrence of PGS were statistically analyzed. Results: The incidence of PGS of the whole group was 1.36% (11/806), which occurred in 7 cases with right colon cancer (63.6%), 3 cases with left colon cancer (27.3%) and one case with rectal cancer (9.1%). Univariate analysis indicated that the related factors for PGS included the preoperative blood sugar level (P=0.002), presence or absence of preoperative electrolyte imbalance (P=0.023), having or not having preoperative intestinal obstruction (P=0.009), and time to first postoperative food intake (P=0.018). Multivariate Logistic regression analysis showed that the preoperative blood sugar level (P=0.002) and time to first postoperative food intake (P=0.028). were independent risk factors for PGS. Conclusion: PGS is a functional abnormality of the stomach caused by various factors, so comprehensive interventions should be implemented. Effective blood glucose control and appropriately prolonging the time to postoperative food consumption may be helpful to reduce the occurrence of PGS following radical resection of colorectal cancer.