文章摘要

微透析技术应用于胰腺研究的现状与展望

作者: 1王丹, 2刘春生, 3周丁华, 1常子倩, 3李爱民
1 中国人民解放军第二炮兵总医院 药剂科，北京 100088
2 中国人民解放军第二炮兵总医院 骨科，北京 100088
3 中国人民解放军第二炮兵总医院 肝胆外科，北京 100088
通讯: 李爱民 Email: liaimin53@sina.com
DOI: 10.3978/.10.3978/j.issn.1005-6947.2015.03.021

摘要

微透析技术（M D）是一种在不破坏机体内环境的前提下，对生物体细胞间液内源性或外源性物 质进行连续取样和分析的微量生化取样技术。MD 不仅可用于监测药物在内脏和肿瘤中的局部药 代动力学，还可研究具有代谢产物与器官特异性的病理生理过程，并且有可能作为器官和肿瘤局部 药物直接传递和评估工具。笔者就MD 在胰腺研究相关应用作一概述，讨论其优势和局限性，并进 行展望。
关键词： 胰腺 微透析技术 综述文献

Microdialysis applied in pancreas research: current status and future prospects

Authors: 1WANG Dan, 2LIU Chunsheng, 3ZHOU Dinghua, 1CHANG Ziqian, 3LI Aimin
1 Department of Pharmacy, the Second Artillery General Hospital, Beijing 100088, China
2 Department of Orthopaedics, the Second Artillery General Hospital, Beijing 100088, China
3 Department of Hepatobiliary Surgery, the Second Artillery General Hospital, Beijing 100088, China

CorrespondingAuthor:LI Aimin Email: liaimin53@sina.com

Abstract

Microdialysis (MD) is a biochemical micro-detection technique that can continuously sample and analyze the endogenous or exogenous substances in the intercellular fluid, with no impact on the internal environment of the organism. MD can be used to determine not only the local drug pharmacokinetics in internal organs or tumors but also the pathophysiological processes that have metabolic products or organ specificity, and even may be used as an approach for direct delivery and assessment of the local drug in organs and tumors. In this paper, the authors address the application of MD in dealing with pancreas-related research, and discuss its advantages and limitations, as well as the future prospects.
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