Objective: To investigate the indications, advantages and complications of using combined brachial and femoral approach for endovascular treatment of subclavian artery occlusion. Methods: Fifty-seven patients with subclavian arterial occlusive disease undergoing endovascular therapy via the combined approach in Department of Vascular Surgery, Xuanwu Hospital of Capital Medical University from January 2011 to June 2014 were reviewed. The pathological characteristics of the patients, success rate of operation, advantages of the combined approach, complications, and follow-up results were analyzed. Results: There was three lesion types among the patients, which included subclavian artery occlusion that failed to be recanalized by anterograde approach (31 cases), the stenosis or occlusion located in the opening of right subclavian artery (16 cases), and the distal subclavian artery stenosis or occlusion adjacent to the opening of the vertebral artery (10 cases). The success rate of endovascular treatment was 91.2% for the entire group, and puncture complications occurred in 3 cases. The stent patency rate at postoperative 6, 12, 24, and 36 months was 100%, 100%, 90% and 77.7%, respectively. Conclusion: For subclavian artery occlusion difficult to be recanalized by conventional approach, the combined approach can effectively improve the recanalization rate, with the advantages of helping to ensure the accuracy of stent positioning and reduce the occurrence of complications.