文章摘要

JAK2-STAT3信号通路在肝细胞癌中的研究进展

作者: 1廖明媚, 1王成志, 1杨满意, 1潘一峰, 1赵劲风
1 中南大学湘雅医院 卫生部纳米生物技术重点实验室，湖南 长沙 410008
通讯: 赵劲风 Email: zhaojinfeng@hotmail.com
DOI: 10.3978/.10.3978/j.issn.1005-6947.2017.01.017
基金: 国家自然科学基金资助项目, 81302075；81272193；81402001

摘要

近年来发现，JAK2-STAT3信号通路参与肿瘤细胞的生长、增殖、分化、转移、凋亡。在肝细胞癌（HCC）细胞中的JAK蛋白和STAT蛋白过表达，JAK2-STAT3信号通路与HCC发生发展密切相关。笔者就JAK2-STAT3信号通路在HCC的研究进展做一综述。
关键词： 癌，肝细胞 Janus激酶类 STAT转录因子类 综述文献

Research progress of JAK2-STAT3 signing pathway in hepatocellular carcinoma

Authors: 1LIAO Mingmei, 1WANG Chengzhi, 1YANG Manyi, 1PAN Yifeng, 1ZHAO Jinfeng
1 Key Laboratory of Nanobiological Technology of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha 410008, China

CorrespondingAuthor:ZHAO Jinfeng Email: zhaojinfeng@hotmail.com

Abstract

In recent years, JAK2-STAT3 signaling pathway has been found to be involved in the growth, proliferation, differentiation, metastasis and apoptosis of tumor cells. JAK and STAT proteins are overexpressed in hepatocellular carcinoma (HCC) cells, and JAK2-STAT3 signaling pathway is closely related to the occurrence and development of HCC. In this article, the authors overview the research progress of JAK2-STAT3 signaling pathway in HCC.
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