文章摘要

结直肠癌患者术前CEA、CA19-9 浓度与临床病理特征及预后的关系

作者: 1钟武, 1张磊昌, 1钟世彪, 1江志远, 1陈利生
1 广西医科大学第一附属医院 结直肠肛门外科,广西 南宁 530021
通讯: 陈利生 Email: clisheng@vip.sina.com
DOI: 10.3978/.10.3978/j.issn.1005-6947.2015.04.008
基金: 国家自然科学基金资助项目, 30760246 2014 年广西研究生教育创新计划资助项目, YCBZ2014032

摘要

目的:探讨结直肠癌患者术前CEA、CA19-9 浓度与临床病理特征及预后的关系。 方法:收集2007 年1 月—2008 年7 月收治并行根治性手术的356 例结直肠癌患者的临床病理资料, 分析血清CEA、CA19-9 与临床病理特征及生存率的关系。 结果:单因素分析结果显示,血清CEA 浓度升高与肿瘤浸润深度、淋巴结转移、病理类型、肝转移、 周围脏器受累有关(均P<0.05);血清CA19-9 浓度升高与肿瘤浸润深度、腹膜转移、肝转移有关(均 P<0.05)。生存分析结果显示,血清CEA 浓度升高患者生存率低于血清CEA 浓度正常患者(P<0.05); 血清CA19-9 浓度升高患者与血清CA19-9 浓度正常患者生存率差异无统计学意义(P>0.05);血清 CEA、CA19-9 浓度同时升高患者与血清CEA 升高或血清CA19-9 升高患者生存率差异无统计学意义(均 P>0.05),但明显低于血清CEA、CA19-9 均正常患者(P<0.05)。 结论:血清CEA、CA19-9 浓度同时升高可能是结直肠癌的晚期事件,提示患者预后不良。
关键词: 结直肠肿瘤 癌胚抗原 CA-19-9 抗原 预后

Relations of preoperative CEA and CA19-9 levels with clinicopathologic profiles and prognosis in colorectal cancer patients

Authors: 1ZHONG Wu, 1ZHANG Leichang, 1ZHONG Shibiao, 1JIANG Zhiyuan, 1CHEN Lisheng
1 Department of Colorectal Surgery, the First Affiliated Hospital, Guangxi Medical University, Nanning 530021, China

CorrespondingAuthor:CHEN Lisheng Email: clisheng@vip.sina.com

Abstract

Objective: To investigate the relations of CA19-9 and CEA levels with clinicopathological features and prognosis of patients with colorectal cancer. Methods: The clinicopathologic data of 356 patients with colorectal cancer undergoing radical surgery from January 2007 to July 2008 were collected. The relations of preoperative CEA and CA19-9 levels and clinicopathologic features and postoperative survival rate of the patients were analyzed. Results: Results of univariate analysis showed that the increased serum CEA level was related to depth of tumor invasion, lymph node metastasis, histological type, liver metastases, peripheral organ involvement (all P<0.05). and the increased serum CA19-9 level was associated with depth of tumor invasion, peritoneal metastasis, and liver metastasis (all P<0.05). Results of survival analysis indicated that survival rate in patients with increased serum CEA level was lower than that in those with normal serum CEA level (P<0.05); survival rate had no statistical difference between patients with increased serum CA19-9 level and normal serum CA19-9 level (P>0.05); survival rate in patients with both increased CEA and CA19-9 levels showed no statistical difference compared to those with increased serum CEA or increased serum CA19-9 level (both P>0.05), but was significantly lower than in those with both normal serum CEA and CA19-9 levels (P<0.05). Conclusion: Simultaneously increased levels of both CEA and CA19-9 is likely related to a late-stage event in colorectal cancer, which suggests an unfavorable prognosis for the patients.
Keywords: