IA期乳腺癌临床病理特征及预后相关因素分析
| 作者: |
1陆宁,
1刘晓东,
1谢晓娟,
1汪旭
1 天津医科大学肿瘤医院 乳腺肿瘤科/国家肿瘤临床医学研究中心/天津市“肿瘤防治”重点实验室/天津市恶性肿瘤临床医学研究中心/乳腺癌防治教育部重点实验室，天津 300060 |
| 通讯: |
陆宁
Email: luning@medmail.com.cn |
| DOI: | 10.3978/.10.3978/j.issn.1005-6947.2016.08.018 |
| 基金: | 国家科技支撑计划资助项目, 2005BAI12B15 |
摘要
目的：探讨IA期乳腺癌患者的临床病理特征与预后因素。方法：回顾性分析2004年1月—2009年12月天津医科大学肿瘤医院收治的156例IA期（T1N0M0，）乳腺癌患者的临床病理资料。结果：156例患者均为女性；病理类型以浸润性导管癌为主（115例，73.7%）；原发肿瘤大小以T1c居多（77例，49.4%）；组织学分级以II级（79例，50.6%）及III级（58例，37.2%）为主。5年无进展生存（PFS）为93.3%，5年总生存（OS）为99.1%。单因素分析结果显示，组织学分级、Ki-67表达及淋巴脉管侵犯与患者的PFS有关（均P<0.05）；多因素分析显示，组织学分级及Ki-67表达情况是影响患者PFS的独立预后因素（均P<0.05）。结论：IA期乳腺癌患者虽然总体预后较好，但对于某些亚组患者而言，预后较差，该类患者的复发转移风险较大。
关键词：
乳腺肿瘤
无病生存
危险因素
Clinicopathologic characteristics and prognostic factors of stage IA breast cancer
CorrespondingAuthor:LU Ning Email: luning@medmail.com.cn
Abstract
Objective: To investigate the clinicopathologic characteristics and prognostic factors of patients with stage IA breast cancer. Methods: The clinicopathologic data of 156 patients with IA stage (T1N0M0) breast cancer treated in Cancer Hospital of Tianjin Medical University from January 2004 to December 2009 were retrospectively analyzed. Results: Of the 156 patients, all cases were female; infiltrate ductal carcinoma accounted for the majority of the pathological types (115 cases, 73.7%), the primary tumor sizes were mostly classified as T1c (77 cases, 49.4%) and histological grades were mainly grade II (79 cases, 50.6%) and III (58 cases, 37.2%). The 5-year progress-free survival (PFS) was 93.3% and overall survival (OS) was 99.1%, respectively. Univariate analysis showed that histological grade, Ki-67 expression and lymphvascular invasion were significantly related to the PFS of the patients (all P<0.05). Multivariate analysis identified that histological grade and Ki-67 expression were independent prognostic factors for PFS of the patients (both P<0.05). Conclusion: Although the overall prognosis of stage IA breast cancer patients is favorable, patients in some subgroups still have great risk of recurrence and metastases, and they have a poor prognosis.
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