文章摘要

长链非编码RNA在肝癌中的研究进展

作者: 1何运, 1陈攀, 1罗嘉, 1吴飞跃
1 湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院 肝胆外科，湖南 长沙 410000
通讯: 吴飞跃 Email: wufeiyue@hnszlyy.com
DOI: 10.3978/.10.3978/j.issn.1005-6947.2016.07.022
基金: 湖南省科学技术厅科技计划基金资助项目, 2011FJ3188 湖南省卫生计生委科研基金资助项目, C2015-53

摘要

长链非编码RNA（lncRNA）是一类200~100 000核苷酸长度且无蛋白质编码功能的一类RNA分子。越来越多的证据表明，lncRNA主要通过在转录、转录后以及表观遗传水平参与基因的表达调控，并以此影响肿瘤细胞的增殖、凋亡、侵袭及转移等过程，与原发性肝癌发生、发展的病理生理机制及患者预后密切相关。原发性肝癌中多种显著异常表达的lncRNA，有望成为原发性肝癌诊断和预后的新的分子标志物。笔者在简要介绍lncRNA的基础上，对近年来lncRNA在肝癌中的研究进展进行综述。
关键词： 癌，肝细胞 长链非编码RNA 预后 综述文献

Long noncoding RNAs in hepatocellular carcinoma: recent research progress

Authors: 1HE Yun, 1CHEN Pan, 1LUO Jia, 1WU Feiyue
1 Department of Hepatobiliary Surgery, Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410000, China

CorrespondingAuthor:WU Feiyue Email: wufeiyue@hnszlyy.com

Abstract

The long non-coding RNAs (lncRNAs) are defined as RNA molecules with a length of 200-100 000 nucleotides that lack protein-coding capacity. Growing evidence indicates that lncRNAs are closely associated with the pathogenesis and progression of hepatocellular carcinoma (HCC) as well as the outcomes of patients, through their participation in regulation of gene expression at transcriptional, post-transcriptional and epigenetic level, and thereby influence the processes of proliferation, apoptosis, angiogenesis, invasion, and metastasis of tumor cells. Some lncRNAs that are aberrantly expressed in HCC may potentially be used for diagnostic or prognostic markers of HCC. In this paper, the authors address the recent research progress of lncRNA in HCC.
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