Objective: To investigate the clinical features, imaging manifestations and differential diagnosis of hepatocellular adenoma (HCA), for its accurate diagnosis and effective treatment. Methods: The clinical data of one HCA patient admitted recently was analyzed retrospectively, and the relevant literature was reviewed. Results: The preoperative imaging examinations of the patient showed a space-occupying lesion in the right lobe of the liver, and all tumor markers were negative but the serum γ-glutamyltransferase level was increased. The patient underwent segment V and partial segment VIII liver resection, and was pathologically diagnosed as HCA of the right hepatic lobe. Postoperative follow-up was conducted for two months, the patient had an uneventful recovery and no abnormality was noted in laboratory parameters or abdominal CT scan during follow-up visits. Conclusion: HCA is a rare benign liver tumor lacking specific clinical signs. Preoperative CT and contrast-enhanced MRI may improve the diagnostic rates of this disease. Surgical resection is the main treatment method for HCA in consideration of its hemorrhagic tendency and the possibility of malignant transformation, and offers favorable results.