Objective: To investigate the risk factors for bleeding after endoscopic submucosal dissection (ESD) in treatment of gastric gastrointestinal stromal tumor (GIST). Methods: The clinical data of 124 patients with gastric GIST undergoing ESD from February 2011 to May 2017 in Renmin Hospital of Wuhan University were retrospectively analyzed. The risk factors for hemorrhage after ESD for gastric GIST were determined by univariate and multivariate unconditional logistic regression analysis. Results: Of the 124 patients enrolled, postoperative bleeding occurred in 10 cases (8.06%). Results of the univariate logistic regression analysis showed that histories of liver cirrhosis, coronary heart disease, old brain infarcts and atrial fibrillation were significantly associated with bleeding after ESD for gastric GIST (all OR>1, P<0.05); further multivariate logistic regression analysis revealed that histories of liver cirrhosis, coronary heart disease, old brain infarcts and atrial fibrillation were independent risk factors for bleeding after ESD for gastric GIST (all OR>1, P<0.05). Conclusion: The histories of liver cirrhosis, coronary heart disease, old brain infarcts and atrial fibrillation are risk factors for bleeding after ESD for gastric GIST. Therefore, the preoperative assessment should be optimized and the pre- and postoperative management should be enhanced in patients with these risk factors, so as to reduce the incidence of postoperative bleeding.