文章摘要

细胞角蛋白19对肝细胞癌生物学行为调控的研究进展

作者: 1刘金生, 1査勇
1 云南省肿瘤医院/昆明医科大学附属第三医院 腹部外科，云南 昆明 650118
通讯: 査勇 Email: zhayong888@sina.com
DOI: 10.3978/.2018.01.017
基金: 国家自然科学基金资助项目（81560497）；云南省应用基础研究计划项目（2015FB073）。

摘要

肝细胞癌（HCC）是消化系统肿瘤中的常见类型之一。近年来已证实细胞角蛋白19（K19）阳性的HCC具有早期转移、低分化与高侵袭性等恶性生物学特性。因此为了更好的明确K19在HCC中对癌症干细胞、血管生成、肿瘤细胞侵袭性以及凋亡的作用以及相关影响，笔者对K19在HCC中的相关生物学行为进行综述。
关键词： 癌，肝细胞；角蛋白19；肿瘤侵润；综述文献

Regulatory role of keratin 19 in biological behaviors of hepatocellular carcinoma: recent progress

Authors: 1LIU Jinsheng, 1ZHA Yong
1 Department of Abdominal Surgery, Yunnan Cancer Hospital/ the Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China

CorrespondingAuthor:ZHA Yong Email: zhayong888@sina.com

Abstract

Hepatocellular carcinoma (HCC) is one of the most common types of tumors of the digestive system. Recent studies have established that keratin 19 (K19) positive HCC is associated with the malignant biological behaviors such as early metastasis, poor differentiation and higher aggressiveness. For better understanding the role of K19 in cancer stem cells, angiogenesis, invasiveness and apoptosis of HCC and its relevant impacts, the authors address the biological actions of K19 in HCC.
Keywords： Carcinoma Hepatocellular; Keratin-19; Neoplasm Invasiveness; Review