文章摘要

活化细胞黏附分子在甲状腺癌中的表达及其临床意义

作者: 1黄荣金, 1林炳煌, 1王进胜, 1何清安, 2杨艺宏
1 泉州医学高等专科学校附属人民医院普通外科，福建 泉州 362000
2 泉州医学高等专科学校附属人民医院病理科，福建 泉州 362000
通讯: 黄荣金 Email: hrongjin2008@126.com
DOI: 10.3978/.10.3978/j.issn.1005-6947.2015.11.014
基金: 福建省卫生厅青年科研课题基金资助项目, 2013-2-130

摘要

目的：研究活化细胞黏附分子（ALCAM）在甲状腺癌组织中表达及其临床意义。方法：免疫组织化学法检测52 例甲状腺癌组织及对应癌旁正常甲状腺组织中ALCAM 的表达，比较ALCAM 在两种组织中表达的差异，并分析其表达与甲状腺癌患者临床病理因素及预后的关系。结果：ALCAM 在甲状腺癌组织中的阳性表达率明显高于癌旁正常甲状腺组织（71.2% vs. 34.6%，P<0.05），但在ALCAM 在甲状腺癌组织中表达越低，甲状腺癌组织病理分化程度越低，患者5 年总生存率越低（均P<0.01）。结论：ALCAM 表达增高可能参与甲状腺癌发生发展进程，然而，在恶性度高、预后差的甲状腺癌的肿瘤组织中ALCAM 表达反而降低的原因推测可能与其脱落释放入血有关。
关键词： 甲状腺肿瘤 活化白细胞黏附分子 预后

Expression and clinical significance of activated-leukocyte adhesion molecule in thyroid carcinoma

Authors: 1HUANG Rongjin, 1LIN Binghuang, 1WANG Jinsheng, 1HE Qing'an, 2YANG Yihong
1 Department of General Surgery, Affiliated People’s Hospital, Quanzhou Medical College, Quanzhou, Fujian 362000, China
2 Department of Pathology, Affiliated People’s Hospital, Quanzhou Medical College, Quanzhou, Fujian 362000, China

CorrespondingAuthor:HUANG Rongjin Email: hrongjin2008@126.com

Abstract

Objective: To investigate the expression of activated-leukocyte adhesion molecule (ALCAM) in thyroid cancer tissue and the clinical significance. Methods: ALCAM expressions in 52 samples of paired thyroid cancer and adjacent normal thyroid tissues were detected by immuohistochemical staining. The ALCAM expression difference between the two types of tissues was compared, and relations of ALCAM expression with clinicopathologic features and prognosis of the thyroid cancer patients were analyzed. Results: The positive ALCAM expression rate in thyroid cancer tissue was significantly higher than that in adjacent normal thyroid tissue (71.2% vs. 34.6%, P<0.05), but in thyroid cancer tissue, the lower ALCAM expression was associated with poorer histopathological differentiation of the thyroid cancer, and shorter 5-year overall survival of the patients (both P<0.01). Conclusion: Increased ALCAM expression may be involved with the occurrence and development of thyroid cancer. However, the phenomenon of ALCAM expression contrarily reduced in tumor tissues from highly malignant and poor prognostic thyroid cancer is speculated to be related to its detachment and release into the circulation.
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