Objective: To assess the application value and efficacy of interventional therapy for hepatic artery complications after liver transplantation. Methods: The diagnosis and treatment as well as the follow-up data of 49 patients with suspicious hepatic artery complications after liver transplantation during January 2006 to January 2012 were retrospectively analyzed. Results: Hepatic artery complications were detected in 26 patients by hepatic arteriography. Hepatic artery stenosis was found in 21 patients, of whom 6 cases with mild and moderate stenosis underwent no treatment; 15 cases with severe stenosis underwent hepatic artery stent placement and intra-stent restenosis developed in 3 of them during follow-up. Pseudoaneurysm formation was found in 2 patients, of whom one case underwent covered stent placement and the aneurysm was completely occluded; one case developed hepatic artery occlusion after undergoing stent-assisted coil embolization, and extensive biliary necrosis occurred at 1.5 months of followup, and then underwent percutaneous transhepatic biliary drainage. Hepatic artery thrombosis was found in 3 patients, of whom one case received transcatheter thrombolysis and no thrombosis formation was observed during 23 months of follow-up; one case with ineffective thrombolysis underwent a second liver transplantation 3 d after interventional treatment; one case with hepatic artery occlusion did not undergo treatment because the collateral circulation was established. Conclusion: Interventional therapy can effectively deal with various hepatic artery complications after liver transplantation and has certain application value in ensuring the success of liver transplantation and improving the survival of the patients.