配对相关同源框-1蛋白在胆囊癌组织中的表达及意义
| 作者: |
1白明辉,
1刘海潮
1 郑州大学附属洛阳中心医院 肝胆疝外科二病区，河南 洛阳 471009 |
| 通讯: |
白明辉
Email: bmh96290@163.com |
| DOI: | 10.3978/.10.3978/j.issn.1005-6947.2017.02.009 |
摘要
目的：探讨配对相关同源框-1蛋白（Prrx-1）在胆囊癌组织中的表达及意义。方法：用免疫组化方法测定Prrx-1在45例胆囊癌及35例胆囊良性病变组织中的表达情况，并分析Prrx-1和胆囊癌临床病理特征之间的关系。结果：Prrx-1在胆囊癌组织中表达率为55.6%（25/45），而在胆囊良性病变组织中的表达率
5.7%（2/35），两者差异有统计学意义（χ2=21.87，P<0.05）。统计分析显示，Prrx-1表达与胆囊癌的组织分化程度、临床分期有关（P<0.05），而与胆囊癌患者的年龄、性别及胆囊癌的组织学类型无关（均P>0.05）。结论：Prrx-1在胆囊癌组织中表达增高，其表达可能在胆囊癌的发生、发展中起重要作用。
关键词：
胆囊肿瘤
同源盒结构域蛋白质类
肿瘤标记，生物学
5.7%（2/35），两者差异有统计学意义（χ2=21.87，P<0.05）。统计分析显示，Prrx-1表达与胆囊癌的组织分化程度、临床分期有关（P<0.05），而与胆囊癌患者的年龄、性别及胆囊癌的组织学类型无关（均P>0.05）。结论：Prrx-1在胆囊癌组织中表达增高，其表达可能在胆囊癌的发生、发展中起重要作用。
Expression and significance of paired-related homeobox 1 protein in gallbladder carcinoma tissue
CorrespondingAuthor:BAI Minghui Email: bmh96290@163.com
Abstract
Objective: To investigate the expression of paired-related homeobox 1 protein (Prrx-1) in gallbladder cancer tissue and its significance. Methods: The Prrx-1 expressions in 45 specimens of gallbladder cancer tissues and 35 specimens of gallbladder tissues with benign diseases were determined by immunohistochemical staining, and the relations of Prrx-1 expression with clinicopathologic profiles of gallbladder cancer were analyzed. Results: The expression rate of Prrx-1 was 55.6% (25/45) in gallbladder cancer tissue, and was 5.7% (2/35) in gallbladder tissue with benign diseases, and the difference between them had statistical significance (χ2=21.87, P<0.05). Statistical analysis indicated that the Prrx-1 expression was closely associated with the degree of differentiation and clinical stage of gallbladder cancer (both P<0.05), but irrelevant to the sex and age of the patients and histological type of gallbladder cancer (all P>0.05). Conclusion: Prrx-1 expression is increased in gallbladder cancer and its expression may be closely connected to the occurrence and development of gallbladder cancer.
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