文章摘要

LPS/TLR4信号通路在肝胆管结石病中的作用及机制研究进展

作者: 1唐世芳, 2赵礼金
1 遵义医学院临床学院，贵州 遵义 563000
2 遵义医学院附属医院 肝胆外科，贵州 遵义 563000
通讯: 赵礼金 Email: Lijinzhao29@sina.com
DOI: 10.3978/.10.3978/j.issn.1005-6947.2017.02.017
基金: 国家自然科学基金资助项目, 81260085 贵州省优秀人才省长专项基金资助项目, 黔省专合字[2011]26号

摘要

肝胆管结石病属于肝胆疾病中常见疾病之一。已证实胆道感染、胆汁淤积、上皮间质转化是该疾病发生发展的重要因素，近年来有研究发现LPS/TLR4通路介导的炎症在这些因素的致病过程中起重要作用。笔者对LPS/TLR4信号通路在肝胆管结石病中的潜在作用及相关机制进行综述，旨在为肝胆管结石病发病机制及防治的研究提供新的思路。
关键词： 胆结石 脂多糖类 Toll样受体4 综述文献

Action and mechanism of LPS/TLR4 signaling pathway in hepatolithiasis: recent progress

Authors: 1TANG Shifang, 2ZHAO Lijin
1 School of Clinical Medicine, Affiliated Hospital, Zunyi Medical University, Zunyi, Guizhou 563000, China
2 Department of Hepatobiliary Surgery, Affiliated Hospital, Zunyi Medical University, Zunyi, Guizhou 563000, China

CorrespondingAuthor:ZHAO Lijin Email: Lijinzhao29@sina.com

Abstract

Hepatolithiasis is one of the common hepatobiliary diseases. It has been confirmed that biliary infection, cholestasis and epithelial mesenchymal transformation are important factors for the occurrence and the development of this condition, and recent studies found that inflammation mediated by LPS/TLR4 pathway plays a crucial role in the pathogenic processes of these factors. Here, the authors address the potential actions and relevant mechanisms of LPS/TLR4 signaling pathway in hepatolithasis, so as to provide new paths to the mechanism research as well as prevention and treatment of hepatolithiasis.
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